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Direct compression excipients: Tablet formulation made simple

Direct compression is the most effective and least complex tablet manufacturing method available to producers today – but to make it a success, brands need the right excipient solutions.

Harder, better, faster, stronger: The benefits of direct compression

In contrast to other common production methods like wet granulation, direct compression requires relatively few processing steps to turn raw ingredients into high quality finished products. This simplicity offers real advantages, including reduced capital investment (in equipment and ingredients), lower labour and energy costs, improved production speed and the ability to work with water-sensitive APIs.

With proper management and the right ingredients, the direct compression method produces safe and effective tablets with no friability, sufficient hardness and a consistent disintegration and dissolution time for optimal effectiveness;

Unlock direct compression with PEARLITOL® SD mannitol

PEARLITOL® SD  is an easy-to-use, spray-dried mannitol specifically designed to enhance direct compression performance.

Like all mannitol excipients, this solution offers excellent compactability and stability properties, a higher intrinsic dissolution rate compared to other binder-fillers, a semi-sweet, cool taste and enhanced flexibility thanks to its chemical inertness. 

The PEARLITOL® SD mannitol difference is that it unlocks the creation of robust, high-quality tablets via direct compression without the need for additives. It also operates on a much wider range of compression forces allowing formulators to adjust manufacturing parameters to compensate for formulation performance fluctuation. 

Available in two grades: PEARLITOL® 100 SD and PEARLITOL® 200 SD, this versatile solution allows formulators to choose the best particle size for their formulation; ensuring uniformity, stability and optimal organoleptic properties for more patient-friendly formulation. 

Ready to get started? Learn more about PEARLITOL® SD mannitol.


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Ready to start your journey?

Your formulations. Our solutions. Your success. Get in touch with our experts to discuss your formulation goals and understand how we can make them a reality.