Introduction of the study
The composition and metabolic activity of the human gut microbiota is inﬂuenced by many factors, including adiposity. Accordingly, there is growing interest in nutritional modulation of the gut microbiota and its implications for obesity and metabolic diseases, such as type 2 diabetes(1). NUTRIOSE®, a wheat dextrin soluble ﬁbre, has been shown to have beneﬁcial effects on markers of insulin resistance(2), appetite regulation(3) and weight management(4), possibly acting via mechanisms governed by the selective modulation of the gut microbiota.
Conclusion of the study
NUTRIOSE® was selectively fermented by Clostridium Cluster XIVa and Roseburia genus in all vessels of the gut model.
NUTRIOSE® favourably altered the metabolic proﬁle of the gut ecosystem, with elevated concentrations of butyrate and propionate, which have both been purported to have energy metabolism and appetite-regulatory properties.