NUTRIOSE^® Soluble Fiber Selectively Modulates Gut Microbiota Composition in Healthy Volunteers

Authors

L. GUERIN-DEREMAUX, ROQUETTE, Lestrem, France 

MR HOBDEN, University of Reading, Department of Food and Nutritional Sciences, Reading, UK  

C. ZHANG, SPRIM, Shanghai, China 

C. NEUT, College of Pharmacy, Clinical Bacteriology Laboratory, INSERM U995 LIRIC, Lille, France 

C. THABUIS, ROQUETTE, Lestrem, France 

R. VAZHAPPILLY, ROQUETTE, Singapor   

GR GIBSON, University of Reading, Department of Food and Nutritional Sciences, Reading, UK 

OB KENNEDY, University of Reading, Department of Food and Nutritional Sciences, Reading, UK 

STUDY OBJECTIVES

• In 2017, the International Scientific Association for Probiotics and Prebiotics (ISAPP) has defined a prebiotic as “a substrate that is selectively utilized by host microorganisms conferring a health benefit”. NUTRIOSE® is a soluble non-viscous fiber produced from wheat, maize or pea starch with supporting science showing that this fiber is slightly digested in the small intestine and progressively fermented all along the colon. 
  The objective of the present research was to investigate the impact of NUTRIOSE® soluble fiber on gut microbiota modulation in healthy volunteers.

METHODS

Study 1

	Healthy volunteers n=12/group France
	14 Days
	Daily intake: - 20g glucose (control) - 10.15 or 20g NUTRIOSE®
	Fecal microbiota using culture methods

Study 2

	Healthy volunteers n=20/group France
	14 Days
	Daily intake: - 8g glucose (control) - 8g NUTRIOSE®
	Fecal microbiota using real-time PCR analysis

Study 3

	Healthy volunteers n=20 normal weight n=16 overweight United Kingdom
	28 Days
	Daily intake: - 7g maltodextrin (control) - 14g NUTRIOSE®
	Fecal microbiota using using fluorescence in situhybridization & 16S rRNA sequencing

Results

Bacteroides

Fig. 1: Fecal Bacteroides
Significant increase in the saccharolytic bacteria following the administration of 10g/day (study 1) or 8g/day (study 2) of NUTRIOSE® compared to baseline.
 

Clostridium cluster IX

Fig. 3: Fecal Clostridium cluster IX
Significant increase in a propionate producing bacterial group.

Clostridium perfringes

Fig. 2: Fecal Clostridium perfringens
Significant decrease following the administration of 15g/day (study 1) or 8g/day (study 2) of NUTRIOSE® compared to baseline.
 

Relative bacterial abundance

Fig. 4: Fecal relative abundance
Significant increase in the saccharolytic Parabacteroides genus, a Bacteroides subgroup of the phylum Bacteroidetes.

CONCLUSIONS

NUTRIOSE® supplementation selectively modulates gut microbiota to a healthier composition. Previously, several studies have demonstrated the health benefits of NUTRIOSE® in blood glucose management, digestive health and sustained energy release. Many of these health benefits produced by NUTRIOSE® were thought to be driven by the selective modulation of the gut microbiota. Collectively all these results show that NUTRIOSE® meets the requirement of the definition of a prebiotic as defined by ISAPP. NUTRIOSE® soluble fiber can be considered as an emerging prebiotic.

DISCLAIMER

FENS 2019 – 13th European Nutrition Conference – October 2019 – Ireland 

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© Roquette Frères S.A. - FENS - 09/2019