Upstream Cell Culture
Roquette’s cell culture solutions are designed to address these challenges by providing reliable, high-purity ingredients that support reproducible results and robust cell proliferation. Each solution is formulated to deliver consistent performance, minimize variability, and integrate seamlessly into diverse bioreactor processes, helping manufacturers achieve greater operational control and efficiency while meeting stringent regulatory requirements.
Cell Culture Solutions for Upstream Biopharma
In upstream biopharmaceutical manufacturing, maintaining consistent cell growth and recombinant protein production can be challenging due to variability in nutrient availability, media composition, and process conditions.
Roquette’s Dextrose Anhydrous Biopharma addresses these challenges by providing a high-purity, readily metabolizable carbohydrate source that fuels robust cell proliferation while minimizing impurities and process variability. Its excellent solubility and consistent performance across small- and large-scale processes ensure that biomanufacturers can achieve reproducible results, maintain product quality, and optimize operational efficiency.
Backed by Roquette’s technical and regulatory expertise, this excipient integrates seamlessly into basal and feed media for a wide variety of cell lines, helping to streamline upstream processes and support reliable biologic production.
Our Solutions
Upstream biomanufacturing faces several critical challenges, including inconsistent cell growth, variable recombinant protein yields, and sensitivity to media composition. These issues can compromise product quality, reduce process efficiency, and increase the risk of batch failures.
Roquette’s cell culture solutions are designed to address these challenges by providing reliable, high-purity ingredients that support reproducible results and robust cell proliferation.
Dextrose Anhydrous Biopharma
Dextrose Anhydrous Biopharma provides a consistent and readily metabolizable energy source to support cell growth and protein expression. Its high purity and low endotoxin content reduce the risk of process variability, while excellent solubility ensures compatibility with batch, fed-batch, and perfusion systems. By stabilizing cell culture performance and supporting reliable product quality, Dextrose Anhydrous Biopharma helps manufacturers overcome one of the most fundamental challenges in upstream bioprocessing: maintaining consistent, reproducible biologic production at scale.
Dextrose Monohydrate Biopharma
LYCADEX® BioPharma low endotoxin grade dextrose monohydrate provides a highly consistent and pure energy source for upstream cell culture applications. Designed to support optimal cell growth and productivity, it helps maintain healthy metabolic activity and stable process yields in biologics manufacturing. Its low endotoxin specification and multi-compendial compliance (EP, USP, JP) make it a trusted choice for demanding biopharmaceutical processes where reliability and reproducibility are essential.
Our Services and Expertise
Roquette provides comprehensive support to ensure that Dextrose Anhydrous Biopharma integrates seamlessly into upstream cell culture processes. Customer Technical Services (CTS) team works closely with biomanufacturers to provide process optimization guidance, troubleshooting support, and assistance with media formulation, helping teams achieve consistent, reproducible results.
Combined with our GMP and compendia-grade quality, which meets global regulatory requirements, these services give manufacturers confidence in compliance, traceability, and product performance. Additionally, Roquette’s robust and secure supply chain ensures uninterrupted production, supporting reliable operations at both small and large scales.
Together, these services help streamline upstream bioprocessing, reduce variability, and maintain high standards of product quality.
Our Applications
Biologics
Stabilizers, cryoprotectants, and process aids for safe, efficient biologic formulation and manufacturing.
Injectables, Dialysis and APIs
High-purity excipients ensuring biocompatibility and isotonicity in parenteral and dialysis applications.
Oral Dosage Solutions
Functional excipients improving flow, compressibility, solubility, and taste for tablets and capsules.