Bioavailability Enhancement for Oral Dosage
Unlock the full therapeutic potential of your oral medications with our advanced bioavailability enhancement solutions. At Roquette, we specialize in overcoming the challenges of poor solubility and chemical instability that can limit drug efficacy. Our innovative excipients, functional starches, and other complementary excipients, improve solubility, protect sensitive APIs, and enhance bioavailability.
Pharmaceutical Solubilization and Stability Enhancers
The success of many oral medicines is impeded by two obstacles: poor solubility and chemical instability. Over 70% of new active pharmaceutical ingredients (APIs) face solubility issues. Even the most effective molecule cannot deliver its therapeutic potential if it fails to dissolve at the right time or degrades before it reaches the patient. For formulators, this means years of research can be compromised by the physical limits of a dosage form.
Roquette helps innovators break through these barriers. Drawing on more than eight decades of expertise in plant-based excipients and breakthrough technologies such as our KLEPTOSE® cyclodextrin range, we provide excipients that improve solubility and dissolution rate, prevent API degradation, extend stability, and mask bitterness. Our portfolio spans versatile cyclodextrins, functional starches, and complementary excipients that protect sensitive actives, enhance bioavailability, and improve patient acceptability through taste masking and ease of use.
Behind every solution is a team of specialists with deep expertise in the science of solubilization and stability. Working alongside your development team, Roquette experts anticipate challenges from lab to scale-up, helping you reach the market faster with safe, robust, and sustainable oral dosage forms.
Enhancing Solubility, Bioavailability, and Stability in Oral Dosage Forms
Over 70% of new APIs face solubility issues, making excipient choice critical. Creating an oral dosage form that dissolves quickly, remains stable, and maintains strength requires excipients engineered for performance. Roquette’s solutions include scientifically proven excipients backed by technical insight and regulatory know-how.
Native beta-cyclodextrins
KLEPTOSE® native beta-cyclodextrin range harnesses inclusion complexation to surround and protect delicate compounds at the molecular level. This interaction enhances aqueous solubility and shields against degradation. They also support taste masking for improved patient compliance. With their plant-based origin, proven safety, and broad pharmacopeial acceptance (EP/USP/JP), they offer a versatile solution for enhancing the stability and patient acceptability of oral formulations.
Hydroxypropyl beta-cyclodextrins
For molecules that demand more power, KLEPTOSE® HPB, HP, and HPB-LB hydroxypropyl beta-cyclodextrin act as advanced solubilizers, providing exceptional capacity to dissolve poorly soluble compounds. They enable higher drug loads and ensure smooth and efficient manufacturing processes, including:
- direct compression
- spray drying
- liquid formulations
Octenyl succinate starches
CLEARGUM® CO octenyl succinate starch is an amphiphilic polymer that performs on multiple fronts. It stabilizes emulsions and suspensions, increases wettability, and accelerates dissolution speed and absorption in oral suspensions. This multifunctional starch is an effective choice for liquid, semi-solid, or fast-dissolving formats.
Integrated formulation support
Choosing the optimal excipient is only part of the solution. Roquette’s Customer Technical Services (CTS) partners with you to evaluate solubilization and stability strategies, helping you select the right technology for your compound. CTS supports customers facing challenges such as formulating with BCS Class II APIs (e.g., poorly soluble compounds) by leveraging hydroxypropyl-beta-cyclodextrin (HPβCD) and effectively boosting solubilization. By combining application testing, formulation expertise, and regulatory insight, CTS ensures your dosage forms achieve robust stability and improved bioavailability from development through scale-up.
Supporting Innovation from Lab to Launch
Behind every high-performing excipient is the know-how to put it to work. Roquette’s role doesn’t end at supplying ingredients. We become an extension of your development team, helping you turn complex solubility or stability challenges into viable, patient-ready products.
Our Customer Technical Services (CTS) is at the heart of this partnership. CTS scientists combine formulation experience, analytical insight, and process knowledge to guide projects from first feasibility tests through scale-up and commercial validation. They understand how small formulation changes can significantly impact dissolution, shelf life, or patient experience, and they bring that expertise directly to you.
Regulatory and quality specialists complement this technical support, helping you navigate global standards so that promising formulations reach patients quickly and compliantly.
This guidance is backed by Roquette’s long heritage in cyclodextrin technology, including pioneering work on KLEPTOSE® cyclodextrin grades that continue to shape how the industry addresses bioavailability and stability.
Innovation also means sustainability: from sourcing plant-based raw materials to developing excipients that support greener manufacturing, we aim to help you build formulations that respect both patients and the planet.
Featured Excipients for Solubility and Stability in Oral Dosage Forms
Explore our leading excipients designed to overcome solubility and stability challenges.
CLEARGUM® CO octenyl succinate starch
Octenyl succinate starch for solubility and stability ideal for syrups, suspensions, and fast-dissolving tablets. Stabilizes emulsions and enhances dissolution, ensuring uniform suspension stability and faster dissolution for improved patient outcomes.
KLEPTOSE® beta-cyclodextrin
A versatile beta-cyclodextrin enhancing solubility and stability through inclusion complexation. Boost formulation performance and patient experience with this plant-based solution with broad pharmacopeial acceptance (EP/USP/JP).
KLEPTOSE® HP, HPB, and HPB-LB hydroxypropyl beta-cyclodextrin
Advanced hydroxypropyl beta-cyclodextrin grades for high-performance solubilization. Support higher drug loads and improved manufacturing efficiency, leading to more reliable patient therapies.