Consistent Disintegration and Dissolution
Roquette provides a wide range of specialized excipients, including superdisintegrants, traditional disintegrants, and multifunctional options like sodium starch glycolate, croscarmellose sodium, starch-based products, and co-processed blends. These solutions cater to the diverse needs of prescription, OTC, and nutraceutical formulations, ensuring rapid and reliable disintegration for tablets, capsules, and ODTs. This enhances consistency in performance and boosts patient adherence.
Disintegrants and Superdisintegrants for Every Dosage Form
Rapid, consistent disintegration is the first step to therapeutic success. Disintegrants and superdisintegrants are essential in pharmaceutical, nutraceutical, and over-the-counter (OTC) dosage forms to ensure rapid breakdown into primary particles, facilitating effective dissolution or release of active ingredients and enhancing patient and consumer experience.
Roquette offers a comprehensive, tailored portfolio of superdisintegrants, traditional disintegrants, and multifunctional excipients such as sodium starch glycolate, croscarmellose sodium, starch-based excipients, and co-processed blends. These excipients are designed to meet diverse formulation challenges and manufacturing processes of prescription, over the counter, and nutraceutical products. They deliver rapid, reproducible disintegration across tablets, capsules, and orally disintegrating tablets (ODTs), supporting consistent performance and improved patient compliance.
Our Disintegrant and Superdisintegrant Solutions
Sodium starch glycolate superdisintegrants
- High-efficiency, versatile excipients suitable for direct compression, wet granulation, and high-shear granulation.
- Stable performance even when combined with lubricants or sensitive APIs.
- Broad regulatory acceptance (EP/USP/JP).
- GLYCOLYS® sodium starch glycolate and EXPLOSOL® sodium starch glycolate ranges include multiple grades tailored to specific manufacturing processes, such as wet granulation and high-shear processes.
Croscarmellose sodium superdisintegrant
- Powerful water absorption for rapid, reproducible disintegration at low inclusion levels.
- Suitable for tablets, capsules, and pellets across prescription (Rx), OTC, and nutraceutical formulations.
- SOLUTAB® croscarmellose sodium enhances dissolution even at low inclusion levels of 2-5%, and helps meet stringent pharmacopeial disintegration requirements.
Traditional disintegrants
- Partially pregelatinized starch ensures rapid disintegration and reliable drug release.
- Provides versatility across different dosage forms.
- Ideal for swallowable tablets and capsules where rapid disintegration is essential, ensuring fast onset of action.
Co-processed excipient solutions
- Multifunctional excipients with self-disintegration properties, enabling fast melt-in-mouth experience for ODTs, chewables, and nutraceuticals.
- StarLac® co-processed lactose-starch offers rapid disintegration and improved mouthfeel.
- PEARLITOL® Flash co-processed mannitol-starch optimizes disintegration, dissolution, and patient experience, ensuring rapid in-mouth disintegration for improved patient compliance, particularly in pediatrics and geriatrics.
Optimizing Disintegration and Dissolution with Roquette Expertise
Roquette combines expertise, innovation, and sustainability to support formulators in developing high-performing dosage forms. Our Customer Technical Services (CTS) laboratories ensure that tablets, capsules, and ODTs perform as intended with practical support such as testing of ODT disintegration times in real-world conditions. With a proven track record in global regulatory compliance, our excipients meet the rigorous standards of Rx, OTC, and nutraceutical products.
In addition, our sustainable, plant-based ingredients reflect our commitment to environmentally conscious solutions, while decades of starch technology experience and innovations in co-processed excipients enable us to offer multifunctional, reliable solutions for a wide range of formulation needs.
Key Pharma Disintegrants and Superdisintegrants
Explore our range of disintegrants and multifunctional excipients designed for tablets, capsules, ODTs, and nutraceuticals.