Discover what makes PEARLITOL® SD mannitol the industry’s first-choice excipient for direct compression, and how it can help you unlock advanced tablet dosage forms.
Roquette excipients for direct compression
Make tablet formulation simple with mannitol PEARLITOL® SD for patient-friendly pharmaceuticals.
Excipients are key ingredients in your direct compression formulation
Direct compression is the most effective and least complex way to produce tablets because it involves minimal process steps. Because of this, it is fast becoming one of the most common and economical methods of tablet manufacturing throughout the pharmaceutical industry.
Direct compression process is expected to deliver a safe and effective tablet with no friability, sufficient hardness and the same disintegration and dissolution time as traditional process.
The chosen excipient for direct compression should aim to deliver these properties.
Mannitol for direct compression
Direct compressional mannitol is a superior excipient with distinct advantages
- Excellent compactability
- Higher intrinsic dissolution rate compared to other binder-fillers
- Compatible with almost all drugs
- Inert substance
- High stability properties
- Produces a semi-sweet, smooth, cool taste (aligned with patient compliance).
Mannitol simplifies the production of tablets without compromising performance
- Compatible with multiple tablet types, including lozenges, swallowable, orally dispersible, chewable, and effervescent.
- Suitable for the rapid release of high-dose or low-dose actives in a range of pharmaceutical and nutraceutical applications.
The PEARLITOL® SD difference
PEARLITOL® SD mannitol is an easy-to-use, spray-dried mannitol with superior performance, designed for direct compression.
The excipient’s outstanding functional properties enable compression of the most challenging and unstable formulations without compromising tablet quality.
PEARLITOL® SD allows the creation of robust, high-quality tablets via direct compression without the need for additives. It also operates on a much wider range of compression forces allowing formulators to adjust manufacturing parameters to compensate for formulation performance fluctuation.
PEARLITOL SD mannitol is available in two grades: PEARLITOL® 100 SD and PEARLITOL® 200 SD. Formulators can choose the particle size most appropriate for their formulation (complementary to the API size); ensuring uniformity, stability and optimal organoleptic properties.
Go deeper with "Your guide to direct compression without compromise" we offer to download below.
PEARLITOL® SD mannitol,
the first-choice excipient for direct compression
- Consistent quality
- Superior, reliable functionality
- Easy-to-use
- Patient-friendly formulation
- Cost savings
- Available in 2 particle sizes
- Technical and formulation support
Discover more about PEARLITOL® SD mannitol
- Reach out to one of our experts to learn more about the excipient and how it can support the success of your direct compression formulation.
- Visit our Pharma Virtual Lab: a 24/7 online and easy-to-use digital platform that offers scientists and developers an opportunity to analyze formulations, read existing Roquette technical research, and inquire directly to the company’s Customer Technical Support team.
Resources
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Explore our full range of excipients, raw materials and actives for pharmaceuticals, nutraceuticals, over-the-counter products, biopharmaceuticals, injectables and dialysis solutions. -
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Pharmaceutical and nutraceutical producers need more than just an ingredient supplier. Discover how our decades of expertise can help you overcome the toughest formulation challenges.
Connect with our experts
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Join Roquette and other experts for this exciting webinar dedicated to cyclodextrin formulations.CEST Time - OnlineRead more
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Join Roquette and Qualicaps at our stand to learn more about our latest innovations.Fiera Milano, ItalyRead more
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Join Roquette and Qualicaps at AAPS 2024 PharmSci 360 to learn more about our solutions.Salt Lake City, Utah, USARead more
Other solutions
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Coating
Use a film coating to mask unpleasant odors and tastes, and protect drugs from environmental factors. A benefit for both patient and laboratory. -
![Close up of a child holding a white tablet on an outstretched tongue.]( "Close up of a child holding a white tablet on an outstretched tongue.")
Disintegrants and Superdisintegrants
Roquette's wide range of disintegration excipients facilitate the dissolution or release of the active ingredients of your capsules or tablets. -
![Close up of young girl with brown hair taking a white tablet, supervised by her parent.]( "Close up of young girl with brown hair taking a white tablet, supervised by her parent.")
Fillers, Diluents and Binders
Discover the variety of fillers, diluents and binders Roquette offers for the formulation of your solid dosage forms. -
![A young boy sat on a large white pillow, taking a liquid solution from a spoon.]( "A young boy sat on a large white pillow, taking a liquid solution from a spoon.")
Liquid solutions
Roquette offers a large range of plant-based excipients for the formulation of liquid forms: syrups, solutions, ampoules, dispersions, etc. -
![Close up of hands pouring a bright pink pharmaceutical syrup onto a spoon.]( "Close up of hands pouring a bright pink pharmaceutical syrup onto a spoon.")
Solubility and stability improvement
Discover a full range range of solubilization and stability enhancers: native and hydroxypropyl cyclodextrins KLEPTOSE®, and octenyl succinate starches CLEARGUM® CO, for use in many dosage forms, from solid to liquid. -
![Close up of a woman feeding a spoonful of medicine to a young girl.]( "Close up of a woman feeding a spoonful of medicine to a young girl.")
Taste-masking
Discover our full range of KLEPTOSE®, efficient taste-masking agents adapted to all process and formulation constraints you might have.
Learn more about our solutions?
Your success is our greatest priority, and your needs are unique. We would love to better understand your needs and connect you with our experts.
Need more information about our solutions for direct compression with mannitol?