PEARLITOL® 150 SD mannitol is a direct compression excipient with low reducing sugar content (300 ppm max). It is a spray-dried form of mannitol with exceptional physical and chemical stability. It offers high API compatibility and no hygroscopicity. It is also a non-cariogenic and non-acidogenic sugar-free sweetener. It is suitable in formulations addressing all types of patient populations including pediatric and diabetic. It can be used in lozenges, swallowable tablets, orally dispersible tablets, chewable tablets, and effervescent tablets.
Water content (LOD)
Water Content (LOD) Maximum: 0.5 %
Average mean particle diameter
Particle Size Distribution by Laser Diffraction
dv10: 60 µm
dv50: 115 µm
dv90: 185 µm
Freely soluble in water (1 part in 5.5 part of water at 20°C), sparingly soluble in 95% ethanol (1 part in 83), practically insoluble in ether
Minimum melting temperature : 165 °C
Maximum melting temperature: 170 °C
Water sorption isotherm at 20°C
Slightly sweet and cooling effect.
Experimental Conditions for Compression Behavior
Tablet Press: STYLCAM 200R
Production Speed: 10, 25 and 40 tablets/min (respective linear punch velocity: 38, 96 and 152 mm/s ; respective simulated rotary press speed: 60000, 150000 and 250000 tablets/hour)
Powder Flowability (according to Ph.Eur. 2.9.16, 10mm outflow opening): 6 s
Bulk Density: 0.46 g/cm3
Tapped Density: 0.55 g/cm3
True Density: 1.514 g/cm3
Specific surface area: 1.3 m2/g
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