MICROCEL® 101 SD Microcrystalline Cellulose and the Granulating Liquid Requirements in High Shear Wet Granulation

High shear wet granulation is a widely used process to improve flow and compactability properties of powders. Microcrystalline cellulose (MCC) is used in this process as filler or secondary binder. Given the interaction between MCC and water, it is crucial to determine the optimal amount of water used during wet granulation as it impacts the resultant granule properties. This video explains the behavior of MCC (MICROCEL® 101 SD) in this process, and through a case study, describes how to determine the amount of water required to obtain granules with the desired properties.

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