Troubleshooting and FAQs for MICROCEL™ Microcrystalline Cellulose

Troubleshooting and FAQs for MICROCEL™ Microcrystalline Cellulose

Frequently asked questions for MICROCEL™ Microcrystalline Cellulose and its applications
  • MICROCEL™ and MICROCEL™ SD are two different microcrystalline cellulose products offered by Roquette. They are produced in two different production sites and both have compliance to all stringent regulatory requirements of U.S. and Europe. Consequently, the physical properties and performance of both microcrystalline cellulose products are not the same.

  • MICROCEL™ is available in different particle sizes, densities and moisture content grades. Depending on your application and formulation, the most appropriate grade may be selected. For example, MICROCEL™ MC-112 is a low moisture grade of microcrystalline cellulose suitable for formulations with moisture instability. For direct compression, MICROCEL™ MC-102 is one of the most commonly used grades.
      MC-101 MC-102 MC-12 MC-200 MC-302 MC-112
    Average Particle Size (µm) 50 100 160 180 100 100
    Loss on Drying (%) ≤ 7 ≤ 7 ≤ 7 ≤ 7 ≤ 7 ≤ 1.5
    Bulk Density (g/cm3) 0.26 – 0.31 0.28 – 0.33 0.30 – 0.40 0.30 – 0.40 0.35 - 0.45 0.28 – 0.33
  • MICROCEL™ is a common tablet filler-binder. When used in direct compression (e.g. MC-102, MC-200 and MC-302), it gives a high tablet strength even at low compression forces. MICROCEL™ may also be used in wet granulation (e.g. MC-101) , dry granulation (e.g. MC-101 and MC-102), or in capsule filling (e.g. MC-102, MC-200 and MC-302).

  • Microcrystalline cellulose is sensitive to over-lubrication due to the fact that it is a plastically deforming material. When this happens, the tablet hardness will be reduced or tablet mechanical failure may be observed. It is recommended to review and optimize your process/formulation to make sure that no over-lubrication is occurring in your blender, press hopper or feed frame.

  • As MICROCEL™ microcrystalline cellulose is a plastically deforming material, it is also strain rate sensitive. Hence, when scaling up the tableting process from lab to pilot/production scale, the higher press speed and consequent reduction in dwell time can cause a loss of tablet hardness. It is advisable to perform "realistic" studies at the R&D stage to avoid scale-up issues later on. At Roquette, we employ the use of compaction simulators in our application labs to mimic industrial tableting conditions, offering "realistic" data and higher chance of success during scale-up.