PEARLITOL® 200 GT mannitol is a direct compression excipient, specially designed to avoid capping, improve flowability and tabletability. It is a granulated form of mannitol with exceptional physical and chemical stability. It offers high API compatibility and no hygroscopicity. It is also a non-cariogenic and non-acidogenic sugar-free sweetener. It is suitable in formulations addressing all types of patient populations including pediatric and diabetic. It can be used in tablets (lozenges, swallowable tablets, orally dispersible tablets, chewable tablets, and effervescent tablets) and in powder blends (sachets, oral stick pack and hard gelatin capsules filling).
Water content (LOD)
Water Content (LOD) Maximum: 0.5 %
Average mean particle diameter
Particle Size Distribution by Laser Diffraction
dv10: 90 µm
dv50: 150 µm
dv90: 260 µm
Freely soluble in water (1 part in 5.5 part of water at 20°C), sparingly soluble in 95% ethanol (1 part in 83), practically insoluble in ether
Minimum melting temperature : 165 °C
Maximum melting temperature: 170 °C
Water sorption isotherm at 20°C
Slightly sweet and cooling effect.
Experimental Conditions for Compression Behavior
Tablet Press: STYLONE EVO
10, 25 and 40 tablets/min (respective linear punch velocity: 38, 96 and 152 mm/s ; respective simulated rotary press speed: 60000, 150000 and 240000 tablets/hour)