KLEPTOSE® HPB-LB Parenteral grade
Hydroxypropyl β-Cyclodextrin - Pyrogen-free - Medium molar substitution
| Product Name | KLEPTOSE® HPB-LB PARENTERAL GRADE |
| Generic Name | Hydroxypropyl-betacyclodextrin HPB and HP-Parenteral grade |
| Physico-chemical properties | |
| Compliance | EP/USP-NF/CHP |
| Synonyms | HYDROXYPROPYLBETADEX |
| CAS Number | 128446-35-5 |
| Chemical Structure |
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| Minimum molecular weight | 1338 g/mol |
| Maximum molecular weight | 1424 g/mol |
| Physical Form or Appearence | White or almost white amorphous powder. The statistical hydroxypropylation of beta-cyclodextrin creates a multitude of molecules, differing by the position of the hydroxypropyl groups. Consequently, the product is not able to crystallize and remains in the amorphous state. |
| Application | KLEPTOSE® HPB-LB parenteral hydroxypropyl β-cyclodextrin. It is a pyrogen-free solution that improves drug solubility and stability against light or oxidation by molecular encapsulation. It also reduces irritation at injection site. KLEPTOSE® HPB-LB is a multi-compendial product that complies with European and U.S. Pharmacopeia, and has standards that not only comply with but are even higher than Chinese Pharmacopeia. |
| Water content (LOD) |
Water Content (LOD) Maximum: 10 % |
| Solubility | Highly soluble in water. At high concentration, the wetting and dissolution time of the powder is delayed due to its low density and increased viscosity. Soluble in ethanol. Freely soluble in propylen glycol. |
| Water sorption isotherm at 20°C |
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| Glass Transition Temperature vs. Water Content |
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| Glass Transition Temperature of the Cryo-Concentrated Phase Tg' | -11.1 °C |
| Viscosity in Water at 20°C |
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