KLEPTOSE® HPB-LB Parenteral grade
Hydroxypropyl β-Cyclodextrin - Pyrogen-free - Medium molar substitution
Product Profile

KLEPTOSE® HPB-LB Parenteral grade
Hydroxypropyl β-Cyclodextrin - Pyrogen-free - Medium molar substitution

 EP/USP/CHP compliance
Product Name KLEPTOSE® HPB-LB PARENTERAL GRADE
Generic Name Hydroxypropyl-betacyclodextrin HPB and HP-Parenteral grade
Physico-chemical properties
Compliance EP/USP-NF/CHP
Synonyms HYDROXYPROPYLBETADEX
CAS Number 128446-35-5
Chemical Structure
Minimum molecular weight 1338 g/mol
Maximum molecular weight 1424 g/mol
Physical Form or Appearence

White or almost white amorphous powder. The statistical hydroxypropylation of beta-cyclodextrin creates a multitude of molecules, differing by the position of the hydroxypropyl groups. Consequently, the product is not able to crystallize and remains in the amorphous state.

Application KLEPTOSE® HPB-LB parenteral hydroxypropyl β-cyclodextrin. It is a pyrogen-free solution that improves drug solubility and stability against light or oxidation by molecular encapsulation. It also reduces irritation at injection site. KLEPTOSE® HPB-LB is a multi-compendial product that complies with European and U.S. Pharmacopeia, and has standards that not only comply with but are even higher than Chinese Pharmacopeia.
Water content (LOD)

Water Content (LOD) Maximum: 10 %

Solubility

Highly soluble in water. At high concentration, the wetting and dissolution time of the powder is delayed due to its low density and increased viscosity. Soluble in ethanol. Freely soluble in propylen glycol.

Water sorption isotherm at 20°C
Glass Transition Temperature vs. Water Content
Glass Transition Temperature of the Cryo-Concentrated Phase Tg' -11.1 °C
Viscosity in Water at 20°C

The information contained in this document is to the best of our knowledge true and accurate, but all instructions, recommendations or suggestions are made without guarantee. Since the conditions of use are beyond our control, we disclaim any liability for loss and/or damage suffered from use of these data or suggestions. Furthermore, no liability is accepted if use of any product in accordance with these data or suggestions infringes any patent. No part of this document may be reproduced by any process without our prior written permission.

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