KLEPTOSE® HPB-LB Parenteral grade
Hydroxypropyl β-Cyclodextrin - Pyrogen-free - Medium molar substitution

Product Profile

KLEPTOSE® HPB-LB Parenteral grade
Hydroxypropyl β-Cyclodextrin - Pyrogen-free - Medium molar substitution

EP/USP/CHP compliance

Product Name	KLEPTOSE® HPB-LB Parenteral grade Pyrogen-free Hydroxypropyl β-cyclodextrin
Synomyms	HYDROXYPROPYLBETADEX
CAS Number	128446-35-5
Chemical Structure
Molecular Weight	1338-1424 g/mol
Physical Form or Appearance	White or almost white amorphous powder. The statistical hydroxypropylation of beta-cyclodextrin creates a multitude of molecules, differing by the position of the hydroxypropyl groups. Consequently, the product is not able to crystallize and remains in the amorphous state.
Application	KLEPTOSE® HPB-LB for parenteral use. It is a pyrogen-free solution that improves drug solubility and stability against light or oxidation by molecular encapsulation. It also reduces irritation at injection site. KLEPTOSE® HPB-LB is a multi-compendial product that complies with European and U.S. Pharmacopeia, and has standards that not only comply with but are even higher than Chinese Pharmacopeia.
Water Content (LOD)	Maximum water content: 10 %
Degree of Substitution	Molar substitution range: 0.50-0.71
Solubility	Highly soluble in water. At high concentration, the wetting and dissolution time of the powder is delayed due to its low density and increased viscosity. Soluble in ethanol. Freely soluble in propylen glycol.
Water sorption isotherm at 20°C
Glass Transition Temperature vs. Water Content
Glass transitiontemperature of the cryo-concentrated phase (Tg’)	Tg’=-11,1°C