KLEPTOSE® HPB Biopharma
Hydroxypropyl β-Cyclodextrin - Low endotoxin - Low molar substitution
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Product Name
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KLEPTOSE® HPB Biopharma Low endotoxin Hydroxypropyl β-cyclodextrin |
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Synomyms |
HYDROXYPROPYLBETADEX |
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CAS Number |
128446-35-5 |
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Chemical Structure
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Molecular weight
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Nominal molecular weight: 1387 g/mol
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Physical Form or Appearence |
White or almost white amorphous powder.
The statistical hydroxypropylation of beta-cyclodextrin creates a multitude of molecules, differing by the position of the hydroxypropyl groups. Consequently, the product is not able to crystallize and remains in the amorphous state. |
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Application |
KLEPTOSE® HPB for biopharma uses. It is a low endotoxin pyrogen-free solution for protein stabilization. It exhibits surface activity and anti-aggregation properties for therapeutic proteins shelf life extension. KLEPTOSE® HPB Biopharma also enables to reduce thermal and agitation sensitivity of formulations. |
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Water Content (LOD) |
Nominal water content: 4 % Maximum water content: 10 % |
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Solubility
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Highly soluble in water. At high concentration, the wetting and dissolution time of the powder is delayed due to its low density and increased viscosity. |
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Water sorption isotherm at 20°C |
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Glass Transition Temperature vs. Water Content
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Glass transition temperature of the cryo-concentrated phase (Tg’) |
Tg’=-10,3°C |
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Viscosity in Water
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Surface tension in Water
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Row:14 Column:1 text
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Osmolality |
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