KLEPTOSE® HPB Biopharma
Hydroxypropyl β-Cyclodextrin - Low endotoxin - Low molar substitution
Product Profile

KLEPTOSE® HPB Biopharma
Hydroxypropyl β-Cyclodextrin - Low endotoxin - Low molar substitution

EP/USP compliance
Product Name

KLEPTOSE® HPB Biopharma Low endotoxin Hydroxypropyl β-cyclodextrin

Synomyms

HYDROXYPROPYLBETADEX

CAS Number

128446-35-5

Chemical Structure
Molecular weight
Nominal molecular weight: 1387 g/mol

Physical Form or Appearence

White or almost white amorphous powder.
The statistical hydroxypropylation of beta-cyclodextrin creates a multitude of molecules, differing by the position of the hydroxypropyl groups. Consequently, the product is not able to crystallize and remains in the amorphous state.

Application

KLEPTOSE® HPB for biopharma uses. It is a low endotoxin pyrogen-free solution for protein stabilization. It exhibits surface activity and anti-aggregation properties for therapeutic proteins shelf life extension. KLEPTOSE® HPB Biopharma also enables to reduce thermal and agitation sensitivity of formulations.

Water Content (LOD)

Nominal water content: 4 %

Maximum water content: 10 %

Solubility

Highly soluble in water. At high concentration, the wetting and dissolution time of the powder is delayed due to its low density and increased viscosity.
Soluble in ethanol.
Freely soluble in propylen glycol.

Water sorption isotherm at 20°C

Glass Transition Temperature vs. Water Content

Glass transition temperature of the cryo-concentrated phase (Tg’)

Tg’=-10,3°C

Viscosity in Water
Surface tension in Water
Row:14 Column:1 text

Osmolality

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