KLEPTOSE® DC
β-cyclodextrin
Product Profile

KLEPTOSE® DC
β-cyclodextrin

Product Name KLEPTOSE® DC
Generic Name Betacyclodextrin
Physico-chemical properties
Compliance EP/USP-NF
Synonyms Beta-cyclodextrin
CAS Number 7585-39-9
Chemical Structure
Average Molecular Weight 1135 g/mol
Physical Form or Appearence White or almost white powder
Application KLEPTOSE® DC β-cyclodextrin is a directly compressible excipient for oral dosage forms. It offers solubility increase through molecular encapsulation.
Water content (LOD)

Nominal water content: 12 %

Water Content (LOD) Maximum: 16 %

Morphology
Average mean particle diameter 80 µm
Particle Size Distribution by Laser Diffraction

dv10: 30 µm

dv50: 90 µm

dv90: 260 µm

Solubility Solubility in water: 18.5 g/l. Practically insoluble in ethanol (95 %)
Melting temperature

Minimum melting temperature : 280 °C

Maximum melting temperature: 300 °C

Water sorption isotherm at 20°C
Taste/Odor Tasteless and odorless
Tablet hardness
Experimental Conditions for Compression Behavior

Tablet Press: STYL'One

Production Speed: simulated rotary press speed: 54000 tablets/hour

Tooling: Diameter 11.28 mm flat

Formula: External lubrication with magnesium stearate

Tablet Mass: 400 mg

Powder Characteristics

Powder Flowability (according to Ph.Eur. 2.9.16, 10mm outflow opening): Need flow aid

Bulk Density: 0.55 g/cm3

Tapped Density: 0.77 g/cm3

True Density: 1.48 g/cm3

Specific surface area: 1.31 m2/g

 

Disclaimer

These typical values are provided for information only and we believe them to be reliable. Methods available upon request.

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