Multivitamin Chewable Tablets Using PEARLITOL® 200 SD Mannitol
Directly compressible formulation for multivitamin chewable tablets
Formula
|
|
Per tablet
|
|---|---|
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Vitamin A (retinol acetate)
|
5000 IU |
|
Vitamin D2 (Ergocalciferol)
|
400 IU
|
|
Vitamin E (DL.α.tocopherol acetate)
|
2 IU
|
|
Vitamin C (L (+) Ascorbic acid)
|
60.0 mg
|
|
Vitamin PP (Nicotinamide)
|
10.0 mg
|
|
Vitamin B2 (Riboflavine)
|
1.5 mg
|
|
Vitamin B1 (Thiamin mononitrate)
|
1.2 mg
|
|
Vitamin B6 (Pyridoxine hydrochloride)
|
1.2 mg
|
|
Vitamin H (D (+) Biotin)
|
40.0 µg
|
|
Vitamin B12 (Cyanocobalamin)
|
3.0 µg
|
|
Magnesium stearate
|
20.0 mg
|
|
Talc
|
10.0 mg
|
|
Orange powder flavor
|
6.0 mg
|
|
AEROSIL® 200 silica*
|
1.5 mg
|
|
Aspartame
|
0.4 mg
|
|
PEARLITOL® 200 SD mannitol
|
q.s. 800.0 mg
|
Method
- Dissolve the vitamins A, B12, D2 and E in a sufficient amount of ethanol.
- Spray the solution on the PEARLITOL® 200 SD using a fluidized bed dryer.
- Evaporate the alcohol.
- Mix all the ingredients except the magnesium stearate for 10 minutes.
- Add the magnesium stearate and mix again for 5 minutes.
- Compress the powder with 13 mm diameter flat face punches.
Additional Comments
- Tablet weight: 800 mg
- Tablet thickness: 5.30 mm
- Tablet density: 1.137 g/cm3
- Tablet hardness: 70 N
Disclaimer
This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s).
These details are for information only and we believe them to be reliable.
*AEROSIL®200 silica is registered trademark of Evonik