Maca chewable tablet formulation for direct compression
Directly compressible formulation of maca chewable tablets using PEARLITOL® 200 SD mannitol as filler-binder to improve poor flow and tabletability of the active ingredient
Objective
Develop a prototype formulation for chewable tablets of maca root powder demonstrating the use of PEARLITOL® 200 SD mannitol as filler-binder to improve poor flow and tabletability of the active ingredient for direct compression process.
Formula
|
Ingredient |
Functionality of the ingredient |
mg/tablet |
% by weight |
|
Maca powder |
Active ingredient |
350 |
70 |
|
PEARLITOL® 200 SD mannitol |
Direct compression filler-binder |
135 |
27 |
|
Silicon dioxide |
Glidant |
10 |
2 |
|
Magnesium stearate |
Lubricant |
5 |
1 |
Method
1. In a mixer, mix PEARLITOL® 200 SD mannitol and silicon dioxide with the maca powder for 5 minutes.
2. Add the magnesium stearate and mix for 5 minutes more.
3. Compress the powder with a 12 mm diameter round concave punch.
Additional comments
|
Tablet hardness |
246 N |
|
Tablet mass |
500 mg |
Comment on Roquette product benefits
PEARLITOL® 200 SD mannitol is a direct compression excipient that confers good flow and tabletability to the formulation. It is a non-cariogenic and non-acidogenic sugar-free sweetener with exceptional physical and chemical stability and no hygroscopicity. It is suitable in formulations addressing all types of patient populations including pediatric and diabetic. It can be used in lozenges, swallowable tablets, orally dispersible tablets, chewable tablets and effervescent tablets.
PEARLITOL® 200 SD is EP/USP-NF/JP/CHP compliant.
® Registered trademark(s) of Roquette Frères.
Disclaimer
This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s).
These details are for information only, and we believe them to be reliable.