Maca chewable tablet formulation for direct compression
Formulation Guideline

Maca chewable tablet formulation for direct compression

Directly compressible formulation of maca chewable tablets using PEARLITOL® 200 SD mannitol as filler-binder to improve poor flow and tabletability of the active ingredient

Objective

Develop a prototype formulation for chewable tablets of maca root powder demonstrating the use of PEARLITOL® 200 SD mannitol as filler-binder to improve poor flow and tabletability of the active ingredient for direct compression process.

Formula

Ingredient

Functionality of the ingredient

mg/tablet
(total weight: 500 mg)

% by weight

Maca powder

Active ingredient

350

70

PEARLITOL® 200 SD mannitol

Direct compression filler-binder

135

27

Silicon dioxide

Glidant

10

2

Magnesium stearate

Lubricant

5

1

Method

1. In a mixer, mix PEARLITOL® 200 SD mannitol and silicon dioxide with the maca powder for 5 minutes.
2. Add the magnesium stearate and mix for 5 minutes more.
3. Compress the powder with a 12 mm diameter round concave punch.

Additional comments

Tablet hardness

246 N

Tablet mass

500 mg

Comment on Roquette product benefits

PEARLITOL® 200 SD mannitol is a direct compression excipient that confers good flow and tabletability to the formulation. It is a non-cariogenic and non-acidogenic sugar-free sweetener with exceptional physical and chemical stability and no hygroscopicity. It is suitable in formulations addressing all types of patient populations including pediatric and diabetic. It can be used in lozenges, swallowable tablets, orally dispersible tablets, chewable tablets and effervescent tablets.
PEARLITOL® 200 SD is EP/USP-NF/JP/CHP compliant.

 

® Registered trademark(s) of Roquette Frères. 

Disclaimer

This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s). 
These details are for information only, and we believe them to be reliable.

 

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