Aspirin oral tablet formulation for direct compression
Formulation Guideline

Aspirin oral tablet formulation for direct compression

Directly compressible formulation of aspirin oral tablets using MICROCEL® MC-101 microcrystalline cellulose (MCC) as filler-binder and SOLUTAB® A croscarmellose sodium as superdisintegrant

Objective

Develop a prototype formulation for aspirin tablets demonstrating the desirable tabletability of MICROCEL® MC-101 microcrystalline cellulose as a filler-binder and SOLUTAB® A croscarmellose sodium as a superdisintegrant.

Formula

Ingredient

Functionality of the ingredient

mg/tablet
(total weight: 600 mg)

% by weight

Aspirin

Active ingredient

500.0

83.33

MICROCEL® MC-101 microcrystalline cellulose

Filler-binder

78.4

13.07

SOLUTAB® A croscarmellose sodium

Superdisintegrant

4.8

0.80

Talc

Glidant

12.0

2.00

Silicon dioxide

Glidant

4.8

0.80

Method

1. Screen the ingredients to remove any clumps.
2. In a mixer, blend MICROCEL® MC-101, aspirin and the silicon dioxide for 20 minutes.
3. Add the talc and SOLUTAB® A, and mix for not more than 5 minutes.
4. Compress the powder with a 12 mm diameter concave punch.

Additional comments

Tablet hardness

80 N

Tablet disintegration time

15 s

Tablet friability

0.6 %

Tablet mass

600 mg

Active ingredient content

500 mg/tablet

Tablet dissolution

> 95 % in 30 min

Comment on Roquette product benefits

MICROCEL® microcrystalline cellulose is used as a filler-binder in various oral dosage forms in both pharmaceutical and nutraceutical applications due to its capacity to provide high tablet hardness. Roquette offers a large range of MICROCEL® in order to meet different formulation and process requirements such as direct compression and wet granulation. 
SOLUTAB® A croscarmellose sodium is a superdisintegrant for swallowable and orally dispersible tablets, hard capsules, blends, granules and pellets premix.  It is flexible as it is adapted to wet and dry granulation or direct compression processes.
MICROCEL® MC-101 and SOLUTAB® A are EP/USP-NF compliant.

 

® Registered trademark(s) of Roquette Frères. 

MICROCEL® is a registered trademark in Benelux, Brazil, Canada, Chile, France, Germany, Italy, Mexico, the United Kingdom, and the United States of America and is pending in other countries or regions.

Disclaimer

This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s). 
These details are for information only, and we believe them to be reliable.

 

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