Direct Compression Solutions
Roquette offers one of the broadest portfolios of excipients designed for direct compression, spanning mannitol, starch-based binders, microcrystalline cellulose, and polyols. These excipients deliver superior compressibility, stability, and patient-pleasing taste and mouthfeel, enabling formulators to meet today’s demands for efficiency and patient compliance.
Specialized Excipients for Direct Compression Success
Direct compression has become the simplest, fastest, and most cost-efficient method of tablet manufacturing. It offers a streamlined alternative to traditional wet granulation, which requires additional processing steps and consumes more energy throughout production. However, harnessing the advantages of direct compression depends on the right choice of excipients.
By reducing processing time and steps, use of Roquette’s excipients reduces processing steps, lowers energy consumption, and shortens time-to-market without compromising tablet quality. With the added support of Roquette’s Customer Technical Services and global regulatory expertise, we help innovators bring reliable, high-quality tablets to market with confidence.
Discover More About Our Solutions
Direct compression depends on excipients that deliver the right balance of flow, compactability, and disintegration. Compared to wet granulation, direct compression simplifies production, minimizes processing time, and reduces energy and material costs, while still delivering tablets with consistent hardness and low friability. Roquette offers a broad selection of options designed to simplify formulation and improve patient experience, ensuring that tablets are efficient to manufacture and reliable in use.
Mannitol forms the foundation of many direct compression projects, offering excellent compactability, chemical stability, and a uniquely pleasant cooling taste. Our PEARLITOL® SD, C, and GT mannitol grades give formulators flexibility in compression forces, while innovative options like PEARLITOL® Flash co-processed mannitol-starch ensures rapid in-mouth disintegration, improving compliance for pediatrics and geriatrics. For moisture-sensitive actives, PEARLITOL® ProTec co-processed mannitol-starch low moisture adds an additional layer of stability.
Starch-based excipients bring another dimension to direct compression performance. From LYCATAB® PGS pregelatinized maize starch that improves flow and binding, to multifunctional starch blends such as LYCATAB® C and CT partially pregelatinized starch and LYCATAB® DSH maltodextrin, these solutions support robust tableting and consistent mechanical strength.
To ensure rapid and reliable tablet breakdown, Roquette also provides GLYCOLYS® sodium starch glycolate, available in potato and maize grades. This proven superdisintegrant helps tablets disintegrate quickly and consistently, supporting both patient compliance and formulation reliability. GLYCOLYS® also helps meet pharmacopeial disintegration standards across prescription (Rx), over the counter (OTC), and nutraceutical products.
Expand possibilities even further with our MICROCEL® microcrystalline cellulose (MCC) grades, which deliver outstanding compressibility and binding, and NEOSORB® P sorbitol grades for direct compression, which offer excellent compactability with a smooth, patient-friendly mouthfeel ideal for chewables and ODTs where sensory properties drive compliance. Together, these excipients give formulators one of the widest toolkits available for direct compression, supported by Roquette’s technical expertise and global regulatory capabilities.
Partner for Success
Roquette supports direct compression formulators with a comprehensive range of services and innovations designed to simplify development and ensure success. Our Customer Technical Services (CTS) team provides hands-on guidance for trials, troubleshooting, and scale-up, helping customers overcome formulation challenges efficiently.
Sustainability is a key focus, with our excipients derived from plant-based starches and sugars to meet growing environmental expectations. In addition, Roquette offers global regulatory expertise, giving formulators confidence that their projects comply with international standards. Combined with our broad excipient portfolio, these services enable formulators to find the right solution for any direct compression project, from initial development to commercial production.
Featured Direct Compression Excipients
Discover our most in-demand excipients designed for consistent performance in direct compression formulations.