Multivitamin Chewable Tablets Using PEARLITOL® 200 SD Mannitol
Published January 27, 2026
Resource
Pharma
Directly compressible formulation for multivitamin chewable tablets
Formula
| Per tablet | |
|---|---|
| Vitamin A (retinol acetate) | 5000 IU |
| Vitamin D2 (Ergocalciferol) | 400 IU |
| Vitamin E (DL.α.tocopherol acetate) | 2 IU |
| Vitamin C (L (+) Ascorbic acid) | 60.0 mg |
| Vitamin PP (Nicotinamide) | 10.0 mg |
| Vitamin B2 (Riboflavine) | 1.5 mg |
| Vitamin B1 (Thiamin mononitrate) | 1.2 mg |
| Vitamin B6 (Pyridoxine hydrochloride) | 1.2 mg |
| Vitamin H (D (+) Biotin) | 40.0 µg |
| Vitamin B12 (Cyanocobalamin) | 3.0 µg |
| Magnesium stearate | 20.0 mg |
| Talc | 10.0 mg |
| Orange powder flavor | 6.0 mg |
| AEROSIL® 200 silica* | 1.5 mg |
| Aspartame | 0.4 mg |
| PEARLITOL® 200 SD mannitol | q.s. 800.0 mg |
Method
- Dissolve the vitamins A, B12, D2 and E in a sufficient amount of ethanol.
- Spray the solution on the PEARLITOL® 200 SD using a fluidized bed dryer.
- Evaporate the alcohol.
- Mix all the ingredients except the magnesium stearate for 10 minutes.
- Add the magnesium stearate and mix again for 5 minutes.
- Compress the powder with 13 mm diameter flat face punches.
Additional Comments
- Tablet weight: 800 mg
- Tablet thickness: 5.30 mm
- Tablet density: 1.137 g/cm3
- Tablet hardness: 70 N
Disclaimer
This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s).
These details are for information only and we believe them to be reliable.
*AEROSIL®200 silica is registered trademark of Evonik