Sugar-free Aspirin Chewable Tablets Using PEARLITOL® 200 SD Mannitol
Published January 27, 2026
Resource
Pharma
Directly compressible formulation of chewable tablets containing Aspirin, a moisture-sensitive API
Formula
| % (By weight) | mg / tablet | |
|---|---|---|
| Aspirin | 50.0 | 500 |
| PEARLITOL® 200 SD mannitol | 43.2 | 432 |
| Stearic acid (< 80 μm) 80=""> | 2.5 | 25 |
| Talc | 2.0 | 20 |
| Orange flavor, powder | 1.5 | 15 |
| Aspartame | 0.5 | 5 |
| AEROSIL® R972 silica* | 0.3 | 3 |
Method
- Introduce in the mixer, the aspirin, silica, flavor and aspartame.
- Mix for 10 minutes.
- Add the talc and PEARLITOL® 200 SD; mix again for 5 minutes.
- Add stearic acid and mix for 5 minutes.
- Compress the powder with round flat face punches of 13 mm diameter.
Additional comments
- Tablet weight: 1000 mg
- Tablet thickness: 6.02 mm
- Tablet density: 1.277 g/cm3
- Tablet Hardness: 87 N
- Dosage: 500 mg / tablet
Disclaimer
This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s).
These details are for information only and we believe them to be reliable.
*AEROSIL® R972 is the registered trademark of Evonik