Fillers for direct compression
Published January 27, 2026
Resource
Pharma
Peer-reviewed journal articles and scientific presentations describing use of PEARLITOL® mannitol, NEOSORB® sorbitol and XYLISORB® xylitol as fillers for direct compression.
| Study Reference | Related Roquette excipient(s) | Summary of results regarding Roquette excipient(s) performances |
|---|---|---|
| Compaction behavior and deformation mechanism of directly compressible textured mannitol in a rotary tablet press simulator Nicolas Tarlier, Ian Soulairol, Bernard Bataille, Gilles Baylac, Patrice Ravel, Isaac Nofrerias, Philippe Lefèvre, Tahmer Sharkawi International Journal of Pharmaceutics 495 (2015) 410–419 https://doi.org/10.1016/j.ijpharm.2015.09.007 | PEARLITOL® 100 SD and PEARLITOL® 200 SD mannitol | The compaction behavior of textured mannitol (PEARLITOL® SD grades) was shown to be unaffected by lubricant concentration or mixing time. It also presented a low strain rate sensitivity (low sensitivity to compression speed variation). All those behaviors are characteristic of fragmentary material. |
| Tableting performance of various mannitol and lactose grades assessed by compaction simulation and chemometrical analysis Shubhajit Paul, Pirjo Tajarobi, Catherine Boissier, Changquan Calvin Sun International Journal of Pharmaceutics 566 (2019) 24–31 https://doi.org/10.1016/j.ijpharm.2019.05.030 | PEARLITOL® 100 SD and PEARLITOL® 200 SD mannitol | Spray-dried mannitol was shown to have a more robust behavior against change in tableting speed. PEARLITOL® 100 SD and 200 SD grades exhibited the lowest strain rate sensitivity. |
| Elastic recovery of filler-binders to safeguard viability of Lactobacillus rhamnosus GG during direct compression Byl Eline, Lebeer Sarah, Kiekens Filip European journal of pharmaceutics and biopharmaceutics - ISSN 0939-6411 - 135(2019), p. 36-43 https://doi.org/10.1016/j.ejpb.2018.12.005 | NEOSORB® P 200 SD (former name: NEOSORB® XTAB 200S), XYLISORB® XTAB 240, PEARLITOL® 200 SD | NEOSORB® and XYLISORB® present the lowest degree of elastic recovery. NEOSORB® produces the hardest tablets at comparable compression pressure. PEARLITOL® 200 SD based tablets present the highest survival rate of probiotic after compression. NEOSORB® XTAB 200S shows one of the lowest viability reduction of cells after storage 3 months at room temperature. |
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