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Antacid Chewable Tablets using PEARLITOL® 160 C Mannitol (Wet Granulation)

Published January 27, 2026

Resource Pharma

Chewable antacid tablets produced via wet granulation containing PEARLITOL® 160 C Mannitol as filler and LYCATAB® DSH Maltodextrin as binder solution

tablet.jpg

Formula

  
 		% (By weight)
 		mg / tablet
 
PEARLITOL® 160 C mannitol
 		70.90567.2
Aluminium hydroxide Al2 (OH)620.00160.0
Magnesium hydroxide Mg (OH)25.0040.0
Magnesium stearate
 		1.5012.0
LYCATAB® DSH maltodextrin (in aqueous solution 10%, w/w)
 		1.3010.4
Buttermint flavor
 		1.008.0
AEROSIL® R 972 silica*
 		0.302.4

Method

  1. Introduce in the planetary mixer the PEARLITOL® 160 C mannitol.
  2. Slowly add the binder solution (LYCATAB® DSH maltodextrin). 
  3. Mixing total time: 20 minutes. 
  4. Introduce this wet mix in the granulator equipped with a wire mesh of 800 µm. 
  5. Dry the granules in a fluidized air bed dryer for 60-70 oC for 30 minutes. 
  6. Introduce all the ingredients except the lubricant in the mixer. 
  7. Mix for 10 minutes.
  8. Add magnesium stearate and mix again for 5 minutes.
  9. Compress the powder to desired tablet shape, size and hardness.

     

Addional comments

  • PEARLITOL® mannitol is used as a filler and filler/binder as well as a bulk sweetener. The PEARLITOL® range offers a unique blend of exceptional physical and chemical stability and no hygroscopicity. With great organoleptic, non-cariogenic and sugar-free properties, PEARLITOL® is suitable to be used in formulations addressing various patient populations including pediatric and diabetic.
  • LYCATAB® DSH maltodextrin is a high-performance wet granulation binder. It is completely soluble in cold water and has excellent wettability. These characteristics make it a versatile excipient for most granulation equipment and for binder incorporation (in the dry mix or as a binder solution).
     

Disclaimer

This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s). 
These details are for information only, and we believe them to be reliable.

*AEROSIL® is registered trademark of Evonik Industries or its subsidiaries.