Taste masked chewable tablet formulation of acetaminophen for direct compression
Published January 27, 2026
SweetPearl® P300 DC maltitol–sucralose formulation for masking the bitterness of acetaminophen.
Objective
Realize a formulation for chewable tablets of acetaminophen with a high capability to mask the bitterness of the API.
Formula
| Ingredient | Functionality of the ingredient | mg/tablet (total weight: 1500mg) | % by weight |
| Acetaminophen powder | Active Pharmaceutical Ingredient | 250 | 16.7 |
| SweetPearl® P300 DC maltitol | Direct compression filler-binder | 1231 | 82 |
| Sucralose | High intensity sweetener | 9 | 0.6 |
| Magnesium stearate | Lubricant | 10 | 0.7 |
Method
- In a mixer, mix the ingredients maltitol, acetaminophen and sucralose for 5 minutes.
- Add the magnesium stearate and mix for 5 minutes more.
- Compress the powder with a 16 mm flat punch.
Additional comments
| Hardness | 100 N |
| Friability test | Passed |
| Tablet thickness | 5.7 mm |
| Tablet mass | 1500 mg |
Comment on Roquette product benefits
SweetPearl® P300 DC maltitol is a direct compression excipient with high chemical stability and low hygroscopicity that is suitable for chewable tablets. Having good flow and compressibility properties, SweetPearl® P300 DC allows simple, easy to produce and cost-effective formulation. It is a non-cariogenic and non-acidogenic sugar-free sweetener. Combined with sucralose, it offers a synergistic bitterness-masking effect for acetaminophen that could be extended to other pediatric formulations.
SweetPearl® P300 DC is EP/USP-NF compliant.
Disclaimer
This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s).
These details are for information only, and we believe them to be reliable.