PEARLITOL® 300 DC - MANNITOL
PEARLITOL®
®Registered Trademark(s) of Roquette Frères
- Designed for direct compression, High density
- Answers a specific need of particle size
Particle size mean diameter - 300 µm approx
Applications
- 1. Solid Forms - Tablets
- Chewable Tablets
- Swallowable Tablets
- Orally Dispersible Tablets
- Effervescent Tablets
- 2. Solid Forms - Capsules
- Hard Capsules Fill
- 5. Other Solid Forms
- Granules and Pellets
- 3. Films and coatings
- Film Coating
Functional properties
- Formulations Aids
- Fillers and Binders for Direct Compression
- Fillers and Binders for Roller Compaction
- Sensory Enhancers
- Sweetening agent
- Stabilizers and Adjusters
- Stabilizers
Physical and chemical properties
- Health & Nutritional Benefits
- Sugar-free
- General Properties
- Label-friendly
- Multicompendial
- Plant-based & non-GMO
Documents
Product Specification Sheet
Name
Region
Size
Download
PEARLITOL® 300 DC
477,30 Ko
Region :
477,30 Ko
PEARLITOL® 300 DC
480,96 Ko
Region :
480,96 Ko
PEARLITOL® 300 DC
480,71 Ko
Region :
480,71 Ko
Safety Data Sheet
Name
Region
Language
Size
Download
PEARLITOL® 300 DC
Europe, BE
EN
520,07 Ko
Region : Europe, BE
EN
520,07 Ko
PEARLITOL® 300 DC
Americas, CA
EN
288,11 Ko
Region : Americas, CA
EN
288,11 Ko
PEARLITOL® 300 DC
Europe, CH
EN
520,42 Ko
Region : Europe, CH
EN
520,42 Ko
PEARLITOL® 300 DC
Asia, CN
EN
328,84 Ko
Region : Asia, CN
EN
328,84 Ko
PEARLITOL® 300 DC
Europe, DE
EN
523,04 Ko
Region : Europe, DE
EN
523,04 Ko
PEARLITOL® 300 DC
Europe, FI
EN
520,11 Ko
Region : Europe, FI
EN
520,11 Ko
PEARLITOL® 300 DC
Europe, FR
EN
520,42 Ko
Region : Europe, FR
EN
520,42 Ko
PEARLITOL® 300 DC
Europe, GB
EN
383,17 Ko
Region : Europe, GB
EN
383,17 Ko
PEARLITOL® 300 DC
Europe, AT
DE
532,59 Ko
Region : Europe, AT
DE
532,59 Ko
PEARLITOL® 300 DC
Europe, BE
DE
532,73 Ko
Region : Europe, BE
DE
532,73 Ko
PEARLITOL® 300 DC
Europe, BE
FR
634,14 Ko
Region : Europe, BE
FR
634,14 Ko
PEARLITOL® 300 DC
Europe, BE
NL
528,74 Ko
Region : Europe, BE
NL
528,74 Ko
PEARLITOL® 300 DC
Europe, BG
BG
678,91 Ko
Region : Europe, BG
BG
678,91 Ko
PEARLITOL® 300 DC
Americas, CA
FR
402,12 Ko
Region : Americas, CA
FR
402,12 Ko
PEARLITOL® 300 DC
Europe, CH
DE
532,92 Ko
Region : Europe, CH
DE
532,92 Ko
PEARLITOL® 300 DC
Europe, CH
FR
634,67 Ko
Region : Europe, CH
FR
634,67 Ko
PEARLITOL® 300 DC
Europe, CH
IT
622,18 Ko
Region : Europe, CH
IT
622,18 Ko
PEARLITOL® 300 DC
Asia, CN
ZH
646,51 Ko
Region : Asia, CN
ZH
646,51 Ko
PEARLITOL® 300 DC
Europe, CZ
CS
652,16 Ko
Region : Europe, CZ
CS
652,16 Ko
PEARLITOL® 300 DC
Europe, DE
DE
537,40 Ko
Region : Europe, DE
DE
537,40 Ko
PEARLITOL® 300 DC
Europe, DK
DA
528,77 Ko
Region : Europe, DK
DA
528,77 Ko
PEARLITOL® 300 DC
Europe, ES
ES
535,29 Ko
Region : Europe, ES
ES
535,29 Ko
PEARLITOL® 300 DC
Europe, FI
FI
536,29 Ko
Region : Europe, FI
FI
536,29 Ko
PEARLITOL® 300 DC
Europe, FR
FR
634,33 Ko
Region : Europe, FR
FR
634,33 Ko
PEARLITOL® 300 DC
Europe, GR
EL
672,26 Ko
Region : Europe, GR
EL
672,26 Ko
Get in touch with our Technical Experts
Please feel free to contact our technical experts for support during the development process.
Technical data
| Synonyms | D-Mannitol |
|---|---|
| CAS number | 69-65-8 |
| Physical form or apperance | White or almost white crystalline powder |
| Application | PEARLITOL® 300 DC mannitol is a high density, direct compression excipient. It offers high API compatibility and no hygroscopicity. It is also a non-cariogenic and non-acidogenic sugar-free sweetener. It is suitable in formulations addressing all types of patient populations including pediatric and diabetic. It can be used in lozenges, swallowable tablets, orally dispersible tablets, chewable tablets, and effervescent tablets. |
| Teste/Odor | Slightly sweet and cooling effect. |
| Morphology |
|
| Water sorption isotherm at 20°C |
|
| Chemical Structure |
|
| Average molecular weight | 182.2 g/mol |
| Maximal Water content (LOD) | 0.50 |
| Solubility | Freely soluble in water (1 part in 5.5 part of water at 20°C), sparingly soluble in 95% ethanol (1 part in 83), practically insoluble in ether |
| Minimum melting temperature | 165 °C |
| Maximum melting temperature | 170 °C |
| Average mean particle diameter | 300 |
| Tablet Hardness |
|
| Experimental Conditions for Compression Behavior_Tablet Press | STYLCAM 200R |
| Experimental Conditions for Compression Behavior_Production Speed | 10, 25 and 40 tablets/min (respective linear punch velocity: 38, 96 and 152 mm/s ; respective simulated rotary press speed: 60000, 150000 and 250000 tablets/hour) |
| Experimental Conditions for Compression Behavior_Tooling | Diameter 10 mm flat |
| Experimental Conditions for Compression Behavior_Formuls | 99% PEARLITOL® 300 DC / 1% magnesium stearate |
| Experimental Conditions for Compression Behavior_Tablet Mass | 400 mg |
| Powder Flowability (according to Ph.Eur. 2.9.16, 10mm outflow opening) | 7 |
| Bulk Density (g/ml) | 0.69 |
| Tapped Density (g/ml) | 0.79 |
| True Density (g/ml) | 1.51 |
| Specific Surface Area (m²/g) | 0.40 |
| Angle of Repose (°) | 28 |