KLEPTOSE® HPB Biopharma
Product Profile

KLEPTOSE® HPB Biopharma

Hydroxypropyl β-Cyclodextrin - Low endotoxin - Medium molar substitution

Product Name
KLEPTOSE® HPB Biopharma low endotoxin hydroxypropyl beta-cyclodextrin
Generic Name
HYDROXYPROPYLBETADEX
Application
KLEPTOSE® HPB for biopharma uses. It is a low endotoxin pyrogen-free solution for protein stabilization. It exhibits surface activity and anti-aggregation properties for therapeutic proteins shelf life extension. KLEPTOSE® HPB Biopharma also enables to reduce thermal and agitation sensitivity of formulations.
Chemical Structure
Hydroxypropyl beta-cyclodextrin molecule
Physical Form
White or almost white amorphous powder.
The statistical hydroxypropylation of beta-cyclodextrin creates a multitude of molecules, differing by the position of the hydroxypropyl groups. Consequently, the product is not able to crystallize and remains in the amorphous state.
Substitution degree
Nominal molar substitution: 0.62; Molar substitution range: 0.58-0.68
Molecular weight
Nominal molecular weight: 1387 g/mol
Moisture Content (LOD)
Nominal water content: 4%; Maximum water content: 10%
Solubility at 20°C
Highly soluble in water. At high concentration, the wetting and dissolution time of the powder is delayed due to its low density and increased viscosity.
Soluble in ethanol.
Freely soluble in propylen glycol.
Vapor Sorption Analysis at 20°C
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Biopharma grade - Water content at equilibrium
Glass transition temperature vs. water content
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Biopharma grade - Glass transition temperature
Glass transition temperature of the cryo-concentrated phase (Tg’)
Tg’=-10.3°C 
Viscosity in water at 20°C
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Biopharma grade - Viscosity
Osmolality
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Biopharma grade - Osmolality
Surface tension
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Biopharma grade - Surface tension