The Health Benefits of NUTRIOSE® Soluble Fiber: The Soluble Fiber NUTRIOSE® Attenuates the Blood Glucose Impact of a High Carbs Intake

Authors

L. GUERIN-DEREMAUX, Roquette, Lestrem, France 

MR HOBDEN, University of Reading, Department of Food and Nutritional Sciences, Reading, UK 

C. THABUIS, Roquette, Lestrem, France 

R. VAZHAPPILLY, Roquette Singapore 

AS VERCRUYSSE, Roquette, Lestrem, France 

OB KENNEDY, University of Reading, Department of Food and Nutritional Sciences, Reading, UK 

STUDY OBJECTIVES

ROQUETTE has developed solutions contributing to the prevention of major health concerns worldwide. Among these solutions, NUTRIOSE® is a soluble non-viscous fiber produced from wheat or maize starch with a fiber content of 85% (on D.S). The objectives of the present research were to demonstrate in healthy volunteers that NUTRIOSE® shows:

	a modulation of gut microbiota
	an attenuation of blood glucose spikes following a carbs challenge
	a sustained release of energy through colonic fermentations

METHODS

Short term impact on glucose management (study 1)

• Cross-over study (Eurofins Optimed)
• Healthy volunteers (n=6)
• 50g intake of NUTRIOSE® or glucose
• 1-day study

Long term impact on microbiota and glucose management (study 2)

• Cross-over study (University of Reading)
• Normal weight (n=20) and overweight (n=16) volunteers
• 14g/day of NUTRIOSE® or an energy-matched placebo as a mid-morning and mid-afternoon drinks
• 28-day study

Sustained energy release (study 3)

• Cross-over study (CRNH Rhône-Alpes)
• Healthy volunteers (n=12) 
• Standardized breakfast with 50g of NUTRIOSE® or maltodextrin enriched in 13C to follow their metabolic fate
• 1-day study

RESULTS

Blood glucose management

Figure 3: Evolution of Glycaemia after carbohydrates challenge

• After 14 and 28 days of NUTRIOSE® consumption, attenuation of the maximum blood glucose concentration following orange juice intake
• AUC (from 0 to 30 min) different at day 14 and day 28 between groups (p<0.05)

NUTRIOSE® limits hyperglycaemic peaks and attenuates the blood glucose impact of carbohydrates intake

Digestive health

Figure 4: Relative abundance using faecal 16S rRNA sequencing 

• Increase in the saccharolytic Parabacteroides genus (a Bacteroides subgroup of the phylum Bacteroidetes) 
• Lower microbial diversity (Shannon Index) in normal weight volunteers (p<0.003); data not shown 

Figure 5: Faecal bacterial data from FISH analysis

• Increase in Clostridium cluster IX, a propionate producing bacterial group 
• Increase in faecal propionate within the NUTRIOSE® group (p<0.05); data not shown

NUTRIOSE® selectively modulates the gut microbiota composition

Sustained energy release

Figure 6: Breath hydrogen response 

• Significant increase in breath H2 excretion 
• Demonstration of prolonged colonic fermentations

Figure 7: Metabolites oxidation levels occuring during intestinal digestion and colonic fermentation through 13CO2 expired 

• Control group: Breath 13CO2 increase shortly after breakfast ingestion, reflecting intestinal digestion into glucose and further glucose oxidation
• NUTRIOSE® group: 
  - Immediate slight 13CO2 appearance reflecting a poor digestion in the small intestine
  - Followed by a steady and prolonged 13CO2 appearance reflecting oxidation of Short Chain Fatty 
    Acids from the prolonged colonic fermentation pattern

NUTRIOSE® displays prolonged colonic fermentations and subsequent prolonged metabolites oxidation

CONCLUSION

NUTRIOSE® acts as a highly targeting prebiotic. This soluble fiber may be used as an integrated solution to improve blood glucose management as NUTRIOSE® helps maintaining healthy blood glucose levels and controls fluctuations after a carbohydrates challenge. Sustained colonic fermentations from NUTRIOSE® contribute to the daily energy supply for whole-body metabolism, and may be a key factor in providing long-lasting energy. The potential health benefits of NUTRIOSE® may be attributed to a specific gut ecosystem modulation

DISCLAIMER

Conflict of interest: Roquette provided financial support for these studies. The authors declare that there is no conflict of interest. 

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