Cyclodextrins

Roquette is a pioneer in the industrial development of Betacyclodextrins. These employ the bio-transformation of starch that results in the Roquette KLEPTOSE® range, adapted for each type of use. Circular molecules “encapsulate” other molecules to form complexes or inclusion compounds, producing modified properties for the “trapped” molecule, available in the final product.

“Native” BetaCycloDextrin KLEPTOSE®


There are mainly used to increase solubility and shelf life, particularly of volatile flavours and fragrances, and can:

  • extract certain undesirable compounds,
  • improve the organoleptic properties by masking odours or tastes,
  • retain or control the release of encapsulated molecules,
  • stabilize against temperature, degradation, hydrolysis and oxidation.

Hydroxypropyl BetacycloDextrins KLEPTOSE®


KLEPTOSE® HP and HPB, Roquette’s Hydroxypropyl betacyclodextrins (HPBCD), are highly soluble betacyclodextrin derivatives - multifunctional excipients for molecular encapsulation suitable for both pharmaceutical (oral and parenteral grades) as well as for cosmetic applications.

KLEPTOSE® HP and HPB are particularly suitable for solving difficulties with aqueous solubility, stability or taste.

Roquette’s pharmaceutical grade HPBCD is produced in a purpose-built, state-of-the-art manufacturing plant conforming to US FDA and ICH Q7A GMP quality guidelines.

CRYSMEB® Methyl Betacyclocextrins


CRYSMEB® is a low methylated betacyclodextrin under development as an easy-to-use solubilizing aid for pharmaceutical formulations, including injectable ones. This product has shown potential as an enabling excipient for challenging formulations.

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