Solubility and stability improvement

We offer a full range range of solubilisation and stability enhancers: native and hydroxypropyl cyclodextrins KLEPTOSE®, and octenyl succinate starches CLEARGUM® CO, for use in many dosage forms, from solid to liquid.

Native betacyclodextrins 

Molecular inclusion complexes using cyclodextrins have become an common formulation strategy to improve the solubility or stability of active ingredients. 

Roquette has pioneered the development of betacyclodextrin technology, developing a full range of KLEPTOSE® betacyclodextrins. With different powder properties, chemical substitutions and solubility profiles, they are able to meet modern formulation needs.

Octenyl succinate starches

CLEARGUM® CO are amphiphilic polymers providing multiple functions:

  • Decreases surface tension for the stability of your emulsions (liquid or solid)
  • Increases wettability of your API and speed of dissolution
  • Improves directly API solubility in water via its stabilization
 

Hydroxypropyl betacyclodextrins

Push back your formulation limits with KLEPTOSE® hydroxypropyl betacyclodextrins enabling technology! For a long time hydroxypropyl betacyclodextrins technology has been used exclusively by a select few. Today, the patent environment for HPBCD is more favourable for new formulations and the use of HPBCD technology in pharmaceuticals is now free of any broad-use restrictions except within the sole US territory till 2019.

You no longer have to let a poorly soluble active ingredients limit your formulation power! 

Download catalogue

Roquette Pharma product catalogue

Find a product

Roquette Pharma product finder

Resources

More details on our selected solutions

Other solutions

  • pharma tablet film coating woman

    Coating

    Use a film coating to mask unpleasant odours and tastes, and protect drugs from environmental factors. A benefit for both patient and laboratory.
  • pharma oral dosage form tablet

    Fillers, Diluents and Binders

    Discover the variety of fillers, diluents and binders Roquette offers for the formulation of your solid dosage forms.
  • Taste-masking child syrup

    Taste-masking

    Discover our full range of KLEPTOSE®, efficient taste masking agents adapted to all process and formulation constraints you might have.
  • pharma orodispersible form

    Disintegrants and Superdisintegrants

    Roquette's wide range of disintegration excipients facilitate the dissolution or release of the active ingredients of your capsules or tablets.
  • pharma-oral-dosage-forms-syrup-little-boy

    Liquid solutions

    Roquette offers a large range of plant-based excipients for the formulation of liquid forms: syrups, solutions, ampoules, dispersions, etc.
Learn more about our solutions?
Your success is our greatest priority, and your needs are unique. We would love to better understand your needs and connect you with our experts.
Need more information about this solution?
Our site uses cookies for web statistics usage and to enhance your user experience. For more information visit our cookie policy and learn how to customize cookies setting.
Click Agree to accept cookies and go directly to the site.
Please, turn your device to portrait mode.