Pharmaceutical fillers, binders and diluents: providing solutions for pharmaceutical industries

Diluents

Diluents are inert powders acting as fillers in the formulation of tablets, capsules and powders for sachets. Roquette offers a range of both water-soluble and water-insoluble diluents that also have a disintegration function.

Starches or partially pregelatinized starches are traditional and trusted insoluble excipients, having the added function of disintegration aid: and extra white maize starch, Wheat starch TB, Potato starch supra NB bacterio, LYCATAB® C partially pregelatinized starch.

Highly functional polyols are appreciated for their physicochemical stability, organoleptic properties (sweetening power, cooling effect) and sugar-free, dietary benefits: NEOSORB® sorbitol powder, PEARLITOL® mannitol powder (crystalline, granulated), SweetPearl® maltitol powder.

The large range of soluble diluents includes also maltodextrins and dried glucose syrups, dextrose monohydrate and dextrose anhydrous.

Microcrystalline Cellulose (MCC) is widely used as a binder/diluent in oral tablet and capsule formulations, typically in dry granulation, wet granulation, and direct compression processes. In addition, MCC may also reduce friction during tablet ejection and facilitate tablet disintegration: MICROCEL™ 101, 102, 12, 112, 200.

Binders for wet granulation

Wet granulation, a traditional manufacturing process, is still widely used. It is often required when the pharmaceutical form contains a high level of active ingredients.

Roquette has specifically developed pharmaceutical binders with different degrees of water solubility or dispersibility.

LYCATAB® PGS is a cold water soluble starch, ideally used in high shear equipment.

LYCATAB® DSH is a water-soluble maltodextrin binder suitable for preparation of granulation solutions or use in dry blends.

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Filler and filler-binder solutions

Enable effective drug manufacturing and enhance patient compliance with our expansive range of reliable fillers and filler-binders.

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Related resources : Pharma - Oral dosage - Fillers Binders and Diluents
Binder solutions

Designed with functionality and flexibility in mind, our range of binders enable robust formulations - no matter the process.

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Related resources : Pharma - Oral dosage - Fillers Binders and Diluents
Brochure : Oral dosage overview

When it comes to meeting the challenges of formulation, you need more than just an ingredient supplier.

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Related resources : Pharma - Oral dosage forms
Leaflet: TABULOSE® SC – Colloidal microcrystalline cellulose

A co-processed product used as a secondary stabilizer and suspension agent in semi-solid formulas.

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Related resources : Pharma - Oral dosage forms
Leaflet: MICROCEL™ - Microcrystalline cellulose

A partially depolymerized cellulose widely used in direct compression or in dry and wet granulation process.

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Related resources : Pharma - Oral dosage forms

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Other solutions

Coating

Use a film coating to mask unpleasant odors and tastes, and protect drugs from environmental factors. A benefit for both patient and laboratory.
Disintegrants and Superdisintegrants

Roquette's wide range of disintegration excipients facilitate the dissolution or release of the active ingredients of your capsules or tablets.
Solubility and stability improvement

Discover a full range range of solubilization and stability enhancers: native and hydroxypropyl cyclodextrins KLEPTOSE®, and octenyl succinate starches CLEARGUM® CO, for use in many dosage forms, from solid to liquid.
Taste-masking

Discover our full range of KLEPTOSE®, efficient taste-masking agents adapted to all process and formulation constraints you might have.
Liquid solutions

Roquette offers a large range of plant-based excipients for the formulation of liquid forms: syrups, solutions, ampoules, dispersions, etc.