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Diluents

Diluents are inert powders acting as fillers in the formulation of tablets, capsules and powders for sachets. Roquette offers a range of both water-soluble and water-insoluble diluents that also have a disintegration function.

Starches or partially pregelatinized starches are traditional and trusted insoluble excipients, having the added function of disintegration aid: and extra white maize starch, Wheat starch TB, Potato starch supra NB bacterio, LYCATAB® C partially pregelatinized starch.

Highly functional polyols are appreciated for their physicochemical stability, organoleptic properties (sweetening power, cooling effect) and sugar-free, dietary benefits: NEOSORB® sorbitol powder, PEARLITOL® mannitol powder (crystalline, granulated), SweetPearl® maltitol powder.

The large range of soluble diluents includes also maltodextrins and dried glucose syrups, dextrose monohydrate and dextrose anhydrous.

Microcrystalline Cellulose (MCC) is widely used as a binder/diluent in oral tablet and capsule formulations, typically in dry granulation, wet granulation, and direct compression processes. In addition, MCC may also reduce friction during tablet ejection and facilitate tablet disintegration: MICROCEL™ 101, 102, 12, 112, 200.

Binders for wet granulation

Wet granulation, a traditional manufacturing process, is still widely used. It is often required when the pharmaceutical form contains a high level of active ingredients.

Roquette has specifically developed pharmaceutical binders with different degrees of water solubility or dispersibility.

LYCATAB® PGS is a cold water soluble starch, ideally used in high shear equipment.

LYCATAB® DSH is a water-soluble maltodextrin binder suitable for preparation of granulation solutions or use in dry blends.

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