When it comes to meeting the challenges of formulation, you need more than just an ingredient supplier.
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Roquette Disintegrants and Superdisintegrants
Disintegrants and superdisintegrants are used in tablets and capsules to ensure the rapid break down into their primary particles, facilitating the dissolution or release of the active ingredients. Roquette has developed a versatile range of standard disintegration excipients.
Roquette Superdisintegrant range: GLYCOLYS® and EXPLOSOL®
GLYCOLYS® and EXPLOSOL® are a range of sodium starch glycolates with various unique grades to meet specific formulation needs:
- GLYCOLYS® LV, for wet granulation and high-shear granulation processes.
- GLYCOLYS® Low pH, suitable for pH sensitive drugs.
- GLYCOLYS®, for all other requirements.
- EXPLOSOL® made with potato or corn, low residual solvents.
The main advantage of Sodium Starch Glycolate is its versatility:
- Suitable for all oral dosage forms (tablets and capsules) and for all manufacturing processes: direct compression or wet granulation, including high-shear granulation processes.
- Efficiency unaffected by lubricants.
- Different modes of incorporation are possible (intra /or extra granularly; even mixed is possible).
SOLUTAB®
Croscarmellose sodium is a highly effective superdisintegrant that also serves as a dissolution aid. The mechanical action is radial expansion due to high capacity of water absorption, allowing complete and efficient distinegration. Croscarmellose is widely used in oral solid pharmaceutical formulas, effective even in low doses and has the ability to regenerate after being moistened.
It is an odorless and white powder, available in different types, such as: SOLUTAB® A, SOLUTAB® A-IP and SOLUTAB® EDP.
Recommended use: It is indicated for use in tablets, capsules and pellets, either in formulas manufactured by direct compression, dry and wet granulation, or with intra or extragranular use.
Recommended concentration: 0.5 to 5.0%, it can be increased or decreased according to the formula need.
Roquette range of disintegrants and self disintegrating compounds
A range of traditional native starches
- Our partially pregelatinized starch LYCATAB® C, which contains native starch which ensures a rapid disintegration and drug release.
- The innovative multifunctional starch compound StarLac®, which consists of lactose and maize starch particles in granular form. With optimized self-disintegration properties, it is therefore well adapted to all types of formulations, especially for tablets requiring fast disintegration.
A mannitol-starch compound
- PEARLITOL® FLASH mannitol-starch compound is an innovative co-processed excipient for orodispersible tablets.
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Customizing appealing dosage forms with the right partner.See brochure -
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A consistent disintegration and dissolution profile is critical for the delivery of your medications’ active ingredients. Discover our solutions.See brochure -
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A superdisintegrant that has excellent performance and cost-benefits.See brochure -
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A highly efficient superdisintegrant with high efficiency even when used in lower doses.See brochure
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Roquette BioPharma solutions
Quality-based, safe, secure, and reliable supply of raw materials and excipients for biologics. -
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Pyrogen-free solutions for life-saving injectables
Pyrogen-free pure materials for parenteral preparations. -
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Direct compression: cost-effective solutions to optimise your formulations
Expertise from lab to pilot to industrial scale and a large range of high-quality excipients to reduce time-to-market. -
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Disintegrants and superdisintegrants solutions
A range of sodium starch glycolates (GLYCOLYS® and EXPLOSOL®) and more than 30 years experience in the field to help in your formulations development. -
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Excipients for solubility and stability improvement & taste masking.
KLEPTOSE® betacyclodextrins range to improve the solubility or stability of active ingredients, or to improve the palatability of drugs. -
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Coating solutions
A natural inert polymer (LYCOAT®) and a ready-to-use coating system (ReadiLYCOAT®) for fast aqueous film coating that saves up to 50% or more time. -
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Orodispersible solutions
Experience a uniquely pleasing taste and a simple tablet formulation thanks to PEARLITOL® Flash mannitol-starch compound.
Other solutions
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Coating
Use a film coating to mask unpleasant odors and tastes, and protect drugs from environmental factors. A benefit for both patient and laboratory. -
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Fillers, Diluents and Binders
Discover the variety of fillers, diluents and binders Roquette offers for the formulation of your solid dosage forms. -
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Solubility and stability improvement
Discover a full range range of solubilization and stability enhancers: native and hydroxypropyl cyclodextrins KLEPTOSE®, and octenyl succinate starches CLEARGUM® CO, for use in many dosage forms, from solid to liquid. -
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Taste-masking
Discover our full range of KLEPTOSE®, efficient taste-masking agents adapted to all process and formulation constraints you might have. -
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Liquid solutions
Roquette offers a large range of plant-based excipients for the formulation of liquid forms: syrups, solutions, ampoules, dispersions, etc.
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