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KLEPTOSE®

Hydroxypropyl Beta-cyclodextrin HPB-LB Parenteral grade

KLEPTOSE® HPB-LB is a hydroxypropyl beta-cyclodextrin parenteral grade material that is used as an encapsulating agent for Rx injectables. It is a modified betacyclodextrin for parenteral use. Modified beta-cyclodextrins used in parenteral preparations provide active substance stabilization improvement against light and oxidation as well as enhancement of solubilization of active pharmaceutical ingredients.

Molecular encapsulation with modified betacyclodextrins has become an accepted and useful tool for pharmaceutical developers.  There are currently several pharmaceutical products containing modified cyclodextrin complexes on the market.  Roquette has pioneered the industrial development of cyclodextrins with its KLEPTOSE® range of betacyclodextrins. 

Hydroxypropyl betacyclodextrin (HPBCD) is a white, amorphous powder.  The HPBCD molecule is a torus shaped ring with a polar hydrophilic outside and an apolar hydrophobic cavity.

® Registered trademark(s) of Roquette Freres
    Pyrogen Free
    Multi-compendial
    Chinese DMF

    Applications

    • Injectables
      • Rx Injectables

    Functional Properties

    • Excipient
      • Encapsulating Agent
      • Solubilizer
      • Stabilizer

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    Product Types

    KLEPTOSE® HP PARENTERAL GRADE - #346114

    Key attributes: High molar substitution (MS) = 0.81 - 0.99

    KLEPTOSE® HPB PARENTERAL GRADE - #346111

    Key attributes: Medium molar substitution (MS) = 0.58 - 0.68

    KLEPTOSE® HPB-LB PARENTERAL GRADE - #346115

    Key attributes: Medium molar substitution (MS) =0.50 - 0.71

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    Regulation & Compliance

    Registrations may vary depending on local regulations

    Compliance

    • European Pharmacopoeia
    • United States Pharmacopeia
    • Chinese Pharmacopeia

    Regulatory

    • A Drug Master File (DMF) is is registered with the Chinese Health Authority. Please contact us to discuss this information

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