Effervescent formulations are produced as solids with intent to transform into a liquid form just before administration. In water, effervescent reaction produces carbon dioxide (CO2) – the fizzing that appeals to consumers along with flavorful additives, providing multi-sensory experience. Effervescent formulations are gaining popularity in prescribed and over-the-counter medications, dietary supplements, as well as energy products. Carbonated liquid dosage forms can speed up adsorption and bioavailability, leading to faster onset of action. Liquid dosage forms are also better tolerated by consumers with dysphagia (children or elderly). Active ingredients upsetting to stomach or difficult to digest, pH-sensitive, or that require large dose may also benefit from administration in a liquid form...
Water-soluble, non-hygroscopic, digestible, and direct compressible filler/binder for effervescent tablet manufacturing is in great need.
SweetPearl® P300 DC is a granulated maltitol specifically designed for direct compression. Distinctive physicochemical properties of maltitol make it an excellent excipient for effervescent formulations. It is low hygroscopic, chemically stable, inert, but at the same time water soluble. Nutritionally, this non-sugar sweetener has good digestive tolerance.
Case study: KLEPTOSE® BIOPHARMA as a potential functional alternative to surfactants within biologic formulationsKLEPTOSE® BioPharma (hydroxypropyl beta cyclodextrin) represents a promising alternative to surfactants commonly used within biologic formulations, such as polysorbates.
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