Starch and starch derivatives, such as sodium starch glycolate, are extensively used as disintegrants for tablets and capsules.
However, starch is considered to be sensitive against film forming on its surface during pharmaceutical manufacturing. Lubricants like Mg stearate could harm its functional properties such as tableting or disintegration.
Unlike starch, the disintegration efficiency of sodium starch glycolate (SSG) has been found to be nearly independent from possible hydrophobic films on its surface. New trials with potato starch and modified potato starch (SSG) should contribute for a better understanding.
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