Designed with functionality and flexibility in mind, our range of binders enable robust formulations - no matter the process.
To improve aqueous solubility and thus the therapeutic effectiveness of such compounds, a number of formulation strategies have been employed.
- Cyclodextrins are cyclic oligosaccharides with a bucket-like structure having a hydrophobic internal cavity and a hydrophilic exterior. This unique structure allows for the formation of inclusion complexes, where lipophilic compounds are non-covalently bound within the cavity.
- Cyclodextrins have been widely used in oral and parenteral drug delivery systems to improve the aqueous solubility and chemical stability of drugs. Topical applications of cyclodextrins have also been investigated.
- Cyclodextrins differ by the number of glucose units forming the ring structure as well as chemical substitutions on the exterior of the ‘bucket’. The influence of side chain substitutions of the cyclodextrin on the solubility of Ibuprofen, a BSC II model compound is essential to understand the complexation process.
Enable effective drug manufacturing and enhance patient compliance with our expansive range of reliable fillers and filler-binders.
Improve consumer compliance by relying on Roquette’s excipients to formulate stable, easy-to-administer Oral Disintegrating Tablets (ODT).
An ageing global population, consumer demand for greater convenience and the need to improve patient compliance are driving the development of new platforms for orally disintegrating dosage forms. Discover Roquette latest innovations.
Customizing oral delivery forms - the healthy way!
Don’t let poor bioavailability hold you back. Advance your oral dosage forms with our versatile solubilizing solutions.