The main objective of this project was to investigate the potential of Kleptose Linecaps DE17 (a pea maltodextrin with a DE range of 15 – 20) in masking the bitter taste of antifungal drug, griseofulvin (GRI) by Hot Melt Extrusion (HME) and to formulate a reconstitutable suspension for pediatric/geriatric patients. The taste masking of bitter APIs is a major challenge especially for pediatrics formulations.

Various reported approaches include, fluidized-bed coating, complexing agents, Pro-drug approach, etc. However, there is an enormous need for more robust, cost effective and easy to scale-up taste masking technologies. Hot Melt Extrusion (HME) is a continuous, one step process which also has been introduced for taste masking purposes of bitter APIs by involving the use of taste masking polymers that create solid dispersions to prevent bitter drugs from coming in contact with the patient’s taste buds.

Other Resources
  • September 13, 2017 Food nutrition FI ASIA 2017
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  • June 23, 2017 Pharma - Oral dosage forms Case study: The excipient of choice for taste masking technology with Hot Melt Extrusion
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  • June 07, 2017 Corporate Roquette invests €40 million in France to reinforce its global leadership in pea protein
  • June 07, 2017 Corporate Roquette invests €40 million in France to reinforce its global leadership in pea protein
  • June 06, 2017 Corporate “Acting and investing sustainably now makes sense more than ever!”
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  • May 31, 2017 Corporate Roquette signs agreement to acquire Itacel and reinforce its global leadership in the pharmaceutical industry.
  • May 31, 2017 Corporate Roquette signs agreement to acquire Itacel and reinforce its global leadership in the pharma industry.
  • May 26, 2017 Food nutrition Roquette showcased new food concepts inspired by consumer insights at Vitafoods 2017.
  • May 22, 2017 Food nutrition Roquette to feature latest innovations in Proteins, Fibers and Sugar Reduction
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