Various reported approaches include, fluidized-bed coating, complexing agents, Pro-drug approach, etc. However, there is an enormous need for more robust, cost effective and easy to scale-up taste masking technologies. Hot Melt Extrusion (HME) is a continuous, one step process which also has been introduced for taste masking purposes of bitter APIs by involving the use of taste masking polymers that create solid dispersions to prevent bitter drugs from coming in contact with the patient’s taste buds.
Case study: KLEPTOSE® BIOPHARMA as a potential functional alternative to surfactants within biologic formulationsKLEPTOSE® BioPharma (hydroxypropyl beta cyclodextrin) represents a promising alternative to surfactants commonly used within biologic formulations, such as polysorbates.
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