KLEPTOSE® HPB Oral grade
Product Profile

KLEPTOSE® HPB Oral grade

Hydroxypropyl β-Cyclodextrin - Medium molar substitution

Product Name

KLEPTOSE® HPB Oral grade
Generic Name
HYDROXYPROPYLBETADEX
Application
KLEPTOSE® HPB Oral grade use is limited to oral dosage forms. It offers taste masking and solubility increase through molecular encapsulation.
Chemical Structure
Hydroxypropyl beta-cyclodextrin molecule
Physical Form
White or almost white amorphous powder.
The statistical hydroxypropylation of beta-cyclodextrin creates a multitude of molecules, differing by the position of the hydroxypropyl groups. Consequently, the product is not able to crystallize and remains in the amorphous state.
Taste / Odor
Slightly sweet
Substitution degree
Nominal molar substitution: 0.62; Molar substitution range: 0.58-0.68
Molecular weight
Nominal molecular weight: 1387 g/mol
Moisture Content (LOD)
Nominal water content: 4%; Maximum water content: 10%
Solubility at 20°C
Highly soluble in water. At high concentration, the wetting and dissolution time of the powder is delayed due to its low density and increased viscosity. 
Soluble in ethanol.
Freely soluble in propylen glycol.
Vapor Sorption Analysis at 20°C
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Oral grade - Water content at equilibrium
Glass transition temperature vs. water content
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Oral grade - Glass transition temperature
Viscosity in water
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Oral grade - Viscosity
Surface tension
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Oral grade - Solution concentration