KLEPTOSE® HPB-LB Parenteral grade
Hydroxypropyl β-Cyclodextrin - Pyrogen-free - Medium molar substitution
Product Profile

KLEPTOSE® HPB-LB Parenteral grade
Hydroxypropyl β-Cyclodextrin - Pyrogen-free - Medium molar substitution

EP/USP/CHP compliance

Product Name

KLEPTOSE® HPB-LB Parenteral grade Pyrogen-free Hydroxypropyl β-cyclodextrin

Synomyms
HYDROXYPROPYLBETADEX
CAS Number

128446-35-5

Chemical Structure
Hydroxypropyl beta-cyclodextrin molecule

Molecular Weight

1338-1424 g/mol

Physical Form or Appearance

White or almost white amorphous powder.
The statistical hydroxypropylation of beta-cyclodextrin creates a multitude of molecules, differing by the position of the hydroxypropyl groups. Consequently, the product is not able to crystallize and remains in the amorphous state. 

Application

KLEPTOSE® HPB-LB for parenteral use. It is a pyrogen-free solution that improves drug solubility and stability against light or oxidation by molecular encapsulation. It also reduces irritation at injection site. KLEPTOSE® HPB-LB is a multi-compendial product that complies with European and U.S. Pharmacopeia, and has standards that not only comply with but are even higher than Chinese Pharmacopeia.

Water Content (LOD)

Maximum water content: 10 %

Degree of Substitution

Molar substitution range: 0.50-0.71

Solubility

Highly soluble in water. At high concentration, the wetting and dissolution time of the powder is delayed due to its low density and increased viscosity.
Soluble in ethanol.
Freely soluble in propylen glycol.

Water sorption isotherm at 20°C

Glass Transition Temperature vs. Water Content

Glass transitiontemperature of the cryo-concentrated phase (Tg’)

Tg’=-11,1°C