KLEPTOSE® HP Parenteral grade
Hydroxypropyl β-Cyclodextrin - Pyrogen-free - High molar substitution
Product Profile

KLEPTOSE® HP Parenteral grade
Hydroxypropyl β-Cyclodextrin - Pyrogen-free - High molar substitution

EP/USP compliance
Product Name

KLEPTOSE® HP Parenteral grade Pyrogen-free Hydroxypropyl β-cyclodextrin

Synonyms
HYDROXYPROPYLBETADEX

CAS Number

128446-35-5

Chemical Structure
Hydroxypropyl beta-cyclodextrin molecule

Molecular Weight

Nominal molecular weight: 1501 g/mol

Physical Form or Appearance

White or almost white amorphous powder.
The statistical hydroxypropylation of beta-cyclodextrin creates a multitude of molecules, differing by the position of the hydroxypropyl groups. Consequently, the product is not able to crystallize and remains in the amorphous state.

Application

KLEPTOSE® HP for parenteral uses. It is a pyrogen-free solution that improves drug solubility and stability against light or oxidation by molecular encapsulation. It also reduces irritation at injection site.

Water Content (LOD)

Nominal water content: 4 %
Maximum water content: 10 %

Degree of Substitution

Nominal molar substitution: 0.9
Molar substitution range: 0.81-0.99

Solubility

Highly soluble in water. At high concentration, the wetting and dissolution time of the powder is delayed due to its low density and increased viscosity.
Soluble in ethanol.
Freely soluble in propylen glycol.

Water sorption isotherm at 20°C

Glass Transition Temperature vs. Water Content
Glass transition temperature of the cryo-concentrated phase (Tg’)
Tg’=-13.5°C 
Viscosity in Water
Surface Tension in Water
Osmolality