KLEPTOSE® HP Parenteral grade
Product Profile

KLEPTOSE® HP Parenteral grade

Hydroxypropyl β-Cyclodextrin - Pyrogen-free - High molar substitution

Product Name

KLEPTOSE® HP Parenteral grade pyrogen-free hydroxypropyl beta-cyclodextrin

Generic Name
HYDROXYPROPYLBETADEX
Application
KLEPTOSE® HP for parenteral uses. It is a pyrogen-free solution that improves drug solubility and stability against light or oxidation by molecular encapsulation. It also reduces irritation at injection site.
Chemical Structure
Hydroxypropyl beta-cyclodextrin molecule
Physical Form

White or almost white amorphous powder.
The statistical hydroxypropylation of betacyclodextrin creates a multitude of molecules, differing by the position of the hydroxypropyl groups. Consequently, the product is not able to crystallize and remains in the amorphous state.

Substitution degree
Nominal molar substitution: 0.9; Molar substitution range: 0.81-0.99
Molecular weight
Nominal molecular weight: 1501 g/mol
Moisture Content (LOD)
Nominal water content: 4%; Maximum water content: 10%
Solubility at 20°C
Highly soluble in water. At high concentration, the wetting and dissolution time of the powder is delayed due to its low density and increased viscosity.
Soluble in ethanol.
Freely soluble in propylen glycol.
Vapor Sorption Analysis at 20°C
KLEPTOSE® HP hydroxypropyl beta-cyclodextrin – Parenteral grade - Water content at equilibrium
Glass transition temperature vs. water content
KLEPTOSE® HP hydroxypropyl beta-cyclodextrin – Parenteral grade - Glass transition temperature
Glass transition temperature of the cryo-concentrated phase (Tg’)
Tg’=-13.5°C 
Viscosity in water
KLEPTOSE® HP hydroxypropyl beta-cyclodextrin – Parenteral grade - Viscosity
Osmolality
KLEPTOSE® HP hydroxypropyl beta-cyclodextrin – Parenteral grade - Osmolality
Surface tension
KLEPTOSE® HP hydroxypropyl beta-cyclodextrin – Parenteral grade - Surface transition