KLEPTOSE® HP Oral grade
Product Profile

KLEPTOSE® HP Oral grade

Hydroxypropyl β-Cyclodextrin - High molar substitution

Product Name

KLEPTOSE® HP Oral grade

Generic Name
HYDROXYPROPYLBETADEX

Application

KLEPTOSE® HP Oral grade use is limited to oral dosage forms. It offers taste masking and solubility increase through molecular encapsulation. 
Chemical Structure
Hydroxypropyl beta-cyclodextrin molecule

Physical Form

White or almost white amorphous powder.
The statistical hydroxypropylation of beta-cyclodextrin creates a multitude of molecules, differing by the position of the hydroxypropyl groups. Consequently, the product is not able to crystallize and remains in the amorphous state.

Morphology
KLEPTOSE® HP hydroxypropyl beta-cyclodextrin - Oral grade
Taste / Odor
Slightly sweet
Substitution degree
Nominal molar substitution: 0.9; Molar substitution range: 0.81-0.99
Molecular weight
Nominal molecular weight: 1501 g/mol
Moisture Content (LOD)

Nominal water content: 4%; Maximum water content: 10%

Solubility at 20°C

Highly soluble in water. At high concentration, the wetting and dissolution time of the powder is delayed due to its low density and increased viscosity. 
Soluble in ethanol.
Freely soluble in propylen glycol.
Vapor Sorption Analysis at 20°C
KLEPTOSE® HP hydroxypropyl beta-cyclodextrin - Oral grade - Water content at equilibrium
Glass transition temperature vs. water content
KLEPTOSE® HP hydroxypropyl beta-cyclodextrin - Oral grade - Glass transition temperature
Viscosity in water at 20°C
KLEPTOSE® HP hydroxypropyl beta-cyclodextrin - Oral grade - Viscosity
Surface tension
KLEPTOSE® HP hydroxypropyl beta-cyclodextrin - Oral grade - Surface tension