KLEPTOSE® HPB Parenteral grade
Product Profile

KLEPTOSE® HPB Parenteral grade

Hydroxypropyl β-Cyclodextrin - Pyrogen-Free - Medium molar substitution

Product Name

KLEPTOSE® HPB Parenteral grade pyrogen-free hydroxypropyl beta-cyclodextrin

Generic Name
HYDROXYPROPYLBETADEX
Application
KLEPTOSE® HPB for parenteral uses. It is a pyrogen-free solution that improves drug solubility and stability against light or oxidation by molecular encapsulation. It also reduces irritation at injection site.
Chemical Structure
Hydroxypropyl beta-cyclodextrin molecule
Physical Form
White or almost white amorphous powder.
The statistical hydroxypropylation of beta-cyclodextrin creates a multitude of molecules, differing by the position of the hydroxypropyl groups. Consequently, the product is not able to crystallize and remains in the amorphous state.
Substitution degree
Nominal molar substitution: 0.62; Molar substitution range: 0.58-0.68
Molecular weight
Nominal molecular weight: 1387 g/mol
Moisture Content (LOD)
Nominal water content: 4%; Maximum water content: 10%
Solubility at 20°C
Highly soluble in water. At high concentration, the wetting and dissolution time of the powder is delayed due to its low density and increased viscosity.
Soluble in ethanol.
Freely soluble in propylen glycol.
Vapor Sorption Analysis at 20°C
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Parenteral grade -  Water content at equilibrium
Glass transition temperature vs. water content
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Parenteral grade - Glass transition temperature
Glass transition temperature of the cryo-concentrated phase (Tg’)
Tg’=-10.3°C 
Viscosity in water 
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Parenteral grade - Viscosity
Osmolality
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Parenteral grade - Osmolality
Surface tension
KLEPTOSE® HPB hydroxypropyl beta-cyclodextrin – Parenteral grade - Surface tension