KLEPTOSE® HPB-LB Parenteral grade
Product Profile

KLEPTOSE® HPB-LB Parenteral grade

Hydroxypropyl β-Cyclodextrin - Medium molar substitution
Global Compliance (EP, US, CHP)

Product Name
KLEPTOSE® HPB-LB Parenteral grade pyrogen-free hydroxypropyl beta-cyclodextrin
Generic Name
HYDROXYPROPYLBETADEX
Application
KLEPTOSE® HPB-LB for parenteral use. It is a pyrogen-free solution that improves drug solubility and stability against light or oxidation by molecular encapsulation. It also reduces irritation at injection site. KLEPTOSE® HPB-LB is a multi-compendial product that complies with European and U.S. Pharmacopeia, and has standards that not only comply with but are even higher than Chinese Pharmacopeia.
Chemical Structure
Hydroxypropyl beta-cyclodextrin molecule
Physical Form
White or almost white amorphous powder.
The statistical hydroxypropylation of beta-cyclodextrin creates a multitude of molecules, differing by the position of the hydroxypropyl groups. Consequently, the product is not able to crystallize and remains in the amorphous state.
Substitution degree
Molar substitution range: 0.50-0.71
Molecular weight
Molecular weight: 1338-1424 g/mol
Moisture Content (LOD)
Maximum water content: 10%
Solubility at 20°C
Highly soluble in water. At high concentration, the wetting and dissolution time of the powder is delayed due to its low density and increased viscosity.
Soluble in ethanol. Freely soluble in propylen glycol.

Vapor Sorption Analysis at 20°C
KLEPTOSE® HPB-LB Parenteral grade - Pyrogen-free hydroxypropyl beta-cyclodextrin - Water content at equilibrium
Glass transition of the cryo-concentrated phase (Tg’)
Tg’=-11.1°C