Troubleshooting and FAQs for NEOSORB® Sorbitol

NEOSORB® sorbitol is available in both crystalline powder P grades and granulated SD grades. Technically, all grades of NEOSORB® are suited for direct compression due to its high tabletability. A lozenge or hard suckable tablet will be obtained with NEOSORB®. Different particle sizes are available depending on the need of the formulation. The spray-dried NEOSORB® SD grades can also be used to adsorb oils/liquids for tablet formulations.

Even though NEOSORB® has a sweet taste (approximately 60% the sweetness of sucrose or xylitol), it is non-cariogenic and hence, a tooth-friendly option for sugar-free formulations.

NEOSORB® SD is the stable γ crystalline form.

Technically, all grades of NEOSORB® are suited for direct compression due to its high tabletibility. Different particle sizes are available depending on the need of the formulation. NEOSORB® SD grades have the highest compactibility and are perfectly adapted to difficult-to-compress APIs.

The NEOSORB® SD Sorbitol product range is well adapted to tablets containing oil(s) due to their high specific areas which enable a high adsorption surface for oily excipients/actives.

It is generally not advisable to use NEOSORB® in wet granulation as sorbitol is highly soluble and can recrystallize as other unstable polymorphs. This can impact your product stability and downstream processes.

As NEOSORB® is a hygroscopic excipient, it is necessary to maintain a low environmental relative humidity (RH) to avoid sticking issues during tableting. A RH of about 40% is typically recommended throughout the manufacturing process. Consideration for moisture-protective packaging is also recommended to ensure stability of the product.

In such cases, you may choose to include a dry binder or a good filler-binder in the formulation. NEOSORB® Sorbitol or MICROCEL^TM Microcrystalline Cellulose are examples of good filler-binders which can increase the overall tablet hardness even when used in small quantities (e.g. 10%).