Troubleshooting and FAQs for NEOSORB® Sorbitol
Troubleshooting

Troubleshooting and FAQs for NEOSORB® Sorbitol

Frequently asked questions for NEOSORB® Sorbitol and its applications
  • NEOSORB® sorbitol is available in both crystalline powder P grades and granulated SD grades. Technically, all grades of NEOSORB® are suited for direct compression due to its high tabletability. A lozenge or hard suckable tablet will be obtained with NEOSORB®. Different particle sizes are available depending on the need of the formulation. The spray-dried NEOSORB® SD grades can also be used to adsorb oils/liquids for tablet formulations.

  • Even though NEOSORB® has a sweet taste (approximately 60% the sweetness of sucrose or xylitol), it is non-cariogenic and hence, a tooth-friendly option for sugar-free formulations.

  • NEOSORB® SD is the stable γ crystalline form.

  • Technically, all grades of NEOSORB® are suited for direct compression due to its high tabletibility. Different particle sizes are available depending on the need of the formulation. NEOSORB® SD grades have the highest compactibility and are perfectly adapted to difficult-to-compress APIs.

  • The NEOSORB® SD Sorbitol product range is well adapted to tablets containing oil(s) due to their high specific areas which enable a high adsorption surface for oily excipients/actives.

  • It is generally not advisable to use NEOSORB® in wet granulation as sorbitol is highly soluble and can recrystallize as other unstable polymorphs. This can impact your product stability and downstream processes.

  • As NEOSORB® is a hygroscopic excipient, it is necessary to maintain a low environmental relative humidity (RH) to avoid sticking issues during tableting. A RH of about 40% is typically recommended throughout the manufacturing process. Consideration for moisture-protective packaging is also recommended to ensure stability of the product.

  • In such cases, you may choose to include a dry binder or a good filler-binder in the formulation. NEOSORB® Sorbitol or MICROCELTM Microcrystalline Cellulose are examples of good filler-binders which can increase the overall tablet hardness even when used in small quantities (e.g. 10%).