Fillers for direct compression
The Science Behind

Fillers for direct compression

Peer-reviewed journal articles and scientific presentations describing use of PEARLITOL® mannitol, NEOSORB® sorbitol and XYLISORB® xylitol as fillers for direct compression.

Study Reference 

Related Roquette excipient(s) 

Summary of results regarding Roquette excipient(s) performances 

Compaction behavior and deformation mechanism of directly compressible textured mannitol in a rotary tablet press simulator  

Nicolas Tarlier, Ian Soulairol, Bernard Bataille, Gilles Baylac, Patrice Ravel, Isaac Nofrerias, Philippe Lefèvre, Tahmer Sharkawi 
International Journal of Pharmaceutics 495 (2015) 410–419 

https://doi.org/10.1016/j.ijpharm.2015.09.007 

PEARLITOL® 100 SD and PEARLITOL® 200 SD mannitol 

The compaction behavior of textured mannitol (PEARLITOL® SD grades) was shown to be unaffected by lubricant concentration or mixing time. It also presented a low strain rate sensitivity (low sensitivity to compression speed variation). All those behaviors are characteristic of fragmentary material. 

Tableting performance of various mannitol and lactose grades assessed by compaction simulation and chemometrical analysis 

Shubhajit Paul, Pirjo Tajarobi, Catherine Boissier, Changquan Calvin Sun 
International Journal of Pharmaceutics 566 (2019) 24–31 

https://doi.org/10.1016/j.ijpharm.2019.05.030  

PEARLITOL® 100 SD and PEARLITOL® 200 SD mannitol 

Spray-dried mannitol was shown to have a more robust behavior against change in tableting speed. PEARLITOL® 100 SD and 200 SD grades exhibited the lowest strain rate sensitivity. 

Elastic recovery of filler-binders to safeguard viability of Lactobacillus rhamnosus GG during direct compression 

Byl Eline, Lebeer Sarah, Kiekens Filip 
European journal of pharmaceutics and biopharmaceutics - ISSN 0939-6411 - 135(2019), p. 36-43

https://doi.org/10.1016/j.ejpb.2018.12.005 

NEOSORB® P 200 SD (former name: NEOSORB® XTAB 200S), XYLISORB® XTAB 240, PEARLITOL® 200 SD 

NEOSORB® and XYLISORB® present the lowest degree of elastic recovery. NEOSORB® produces the hardest tablets at comparable compression pressure. 

PEARLITOL® 200 SD based tablets present the highest survival rate of probiotic after compression. 

NEOSORB® XTAB 200S shows one of the lowest viability reduction of cells after storage 3 months at room temperature. 

® Registered trademark(s) of Roquette Frères. 

  

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