The compaction behavior of textured mannitol (PEARLITOL® SD grades) was shown to be unaffected by lubricant concentration or mixing time. It also presented a low strain rate sensitivity (low sensitivity to compression speed variation). All those behaviors are characteristic of fragmentary material.
Tableting performance of various mannitol and lactose grades assessed by compaction simulation and chemometrical analysis
Shubhajit Paul, Pirjo Tajarobi, Catherine Boissier, Changquan Calvin Sun
International Journal of Pharmaceutics 566 (2019) 24–31