Fillers for direct compression
Peer-reviewed journal articles and scientific presentations describing use of PEARLITOL® mannitol, NEOSORB® sorbitol and XYLISORB® xylitol as fillers for direct compression.
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Study Reference |
Related Roquette excipient(s) |
Summary of results regarding Roquette excipient(s) performances |
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Compaction behavior and deformation mechanism of directly compressible textured mannitol in a rotary tablet press simulator |
PEARLITOL® 100 SD and PEARLITOL® 200 SD mannitol |
The compaction behavior of textured mannitol (PEARLITOL® SD grades) was shown to be unaffected by lubricant concentration or mixing time. It also presented a low strain rate sensitivity (low sensitivity to compression speed variation). All those behaviors are characteristic of fragmentary material. |
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Tableting performance of various mannitol and lactose grades assessed by compaction simulation and chemometrical analysis |
PEARLITOL® 100 SD and PEARLITOL® 200 SD mannitol |
Spray-dried mannitol was shown to have a more robust behavior against change in tableting speed. PEARLITOL® 100 SD and 200 SD grades exhibited the lowest strain rate sensitivity. |
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Elastic recovery of filler-binders to safeguard viability of Lactobacillus rhamnosus GG during direct compression |
NEOSORB® P 200 SD (former name: NEOSORB® XTAB 200S), XYLISORB® XTAB 240, PEARLITOL® 200 SD |
NEOSORB® and XYLISORB® present the lowest degree of elastic recovery. NEOSORB® produces the hardest tablets at comparable compression pressure. |
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