Continuous wet granulation binders
The Science Behind

Continuous wet granulation binders

Peer-reviewed journal articles and scientific presentations describing the use of CLEARGUM® octenyl succinate starch and LYCOAT® hydroxypropyl pea starch as granulation binders in a continuous granulation process.

Study Reference 

Related Roquette excipient(s) 

Summary of results regarding Roquette excipient(s) performances 

Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition  

Vandevivere, L.; Denduyver, P.; Portier, C.; Häusler, O.; De Beer, T.; Vervaet, C.; Vanhoorne, V. International Journal of Pharmaceutics, 2020; 585 
https://doi.org/10.1016/j.ijpharm.2020.119466 

 

CLEARGUM® CO 03 octenyl succinate starch; LYCOAT® RS 720 hydroxypropyl pea starch 

Both CLEARGUM® CO 03 and LYCOAT® RS 720 present good binding properties on a hydrophobic dicalcium phosphate (DCP) powder. Owing to its low surface tension in water, CLEARGUM® offered very good wettability of the DCP. 

Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation 

Vandevivere, L.; Vangampelaere, M.; Portier, C.; de Backere, C.; Häusler, O.; De Beer, T.; Vervaet, C.; Vanhoorne, V. Pharmaceutics, 2020; 210 
https://doi.org/10.3390/pharmaceutics13020210 

CLEARGUM® CO 01 octenyl succinate starch; LYCOAT® RS 720 Hydroxypropyl starch 

Both CLEARGUM® CO 01 and LYCOAT® RS 720 present good overall binding properties. Due to its low surface tension in water, CLEARGUM® CO 01 is more efficient for hydrophobic powder (DCP) granulation. At the same time, LYCOAT® RS 720 presents better efficacy to granulate hydrophilic powder (mannitol). 

® Registered trademark(s) of Roquette Frères. 

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