KLEPTOSE® HP (hydroxypropyl-beta-cyclodextrin)
KLEPTOSE® CRYSMEB (methyl-beta-cyclodextrin)
Both β-cyclodextrin derivatives were used successfully to formulate nebulizable solutions of formoterol. The cyclodextrin/formoterol aqueous solutions were able to form aerosols with particle size suitable for pulmonary deposition.
Pharmacodynamic and pharmacokinetic investigation of cyclodextrin-mediated asenapine maleate in situ nasal gel for improved bioavailabilty.
Kulkarni, J.A.; Avachat, A.M. Drug development and industrial pharmacy. 2017 Feb 1;43(2):234-45.
An in situ nasal gel of asenapine maleate (AM)-HPβCD inclusion complex for the treatment of schizophrenia and bipolar disorder I was successfully developed. 1:1 molar ratio complexation with hydroxypropyl beta-cyclodextrin was used to improve solubility of AM through a kneading process.
Cyclodextrins as a potential carrier in drug nebulization
Evrard, B.; Bertholet, P.; Gueders, M.; Flament, M.-P.; Piel, G.; Delattre, L.; Gayot, A.; Leterme, P.; Foidart, J.-M.; Cataldo, D. Journal of Controlled Release. 2004 May 18;96(3):403-10.
Hydroxypropyl-beta-cyclodextrin was shown to undergo aerosolization and that the resulting droplet-size is compatible with pulmonary deposition. In vivo, it was demonstrated that inhaled hydroxypropyl beta-cyclodextrin solutions were non-toxic as assessed by the study of BAL, lung and kidney histology, bronchial responsiveness to methacholine and blood urea.
Development of a Taste-Masked Orodispersible Film Containing Dimenhydrinate
Preis, M.; Pein, M.; Breitkreutz. J. Pharmaceutics. 2012 Dec;4(4):551-62.
Hydroxypropyl-beta-cyclodextrin and pea maltodextrin were able to improve the solubility of dimenhydrinate and could prevent the recrystallization of the drug substance in solid state of the film. Both excipients also demonstrated taste-masking effects through electronic tongue evaluation.
Contribution of cyclodextrins in the development of different pharmaceutical formulations of a new matrix metalloproteinase inhibitor
Evrard, B.; Bertholet, P.; Gueders, M.; Piette, M.; Piel, G.; Cataldo, D.; Delattre, L. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2007 Apr 1;57(1-4):303-8. https://doi.org/10.1007/s10847-006-9177-z
KLEPTOSE® HPB (hydroxypropyl-beta-cyclodextrin)
Hydroxypropyl beta-cyclodextrin was able to improve the aqueous solubility of Ro 28-2653 (5-biphenyl-4-yl-5-[4-(4-nitro-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione) (RO) when mixed with randomly methylated-b-CD (RAMEB). There was also a synergistic effect between L-lysine with hydroxypropyl-beta-cyclodextrin that resulted in a significant increase in RO aqueous solubility (70,000 times).
Optimization of Drug Permeation from 8% Ciclopirox Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers
KLEPTOSE® (beta-cyclodextrin) and KLEPTOSE® CRYSMEB (methyl-beta-cyclodextrin)
Inclusion complex of 1:1 molar ratio was formed between omeprazole and both beta-cyclodextrin and methyl-beta-cyclodextrin via a freeze-drying method. In addition, inclusion complex was also formed with methyl-beta-cyclodextrin via spray-drying. Significant improvement of dissolution (p < 0.001) was observed by the complexed forms versus a physical mixture control.