Superdisintegrants in Orally Disintegrating Tablets (ODT)
Peer-reviewed journal articles and scientific presentations describing the use of StarLac® co-processed lactose starch and PEARLITOL® Flash co-processed mannitol-starch as superdisintegrants in ODTs
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Study Reference |
Related Roquette excipient(s) |
Summary of results regarding Roquette excipient performances |
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Taste-masked and affordable donepezil hydrochloride orally disintegrating tablet as promising solution for non-compliance in Alzheimer’s disease patients
Liew, K.B.; Tan, Y.T.; Peh, K.K. Drug development and industrial pharmacy. 2015 Apr 3;41(4):583-93. https://doi.org/10.3109/03639045.2014.884130 |
StarLac® Co-processed Lactose Starch |
Formulation containing 50% of StarLac® was found with shortest in vitro, in vitro in artificial saliva and in vivo disintegration times, respectively (21.7 ± 1.67 s), (22.5 ± 1.67 s) and (24.0 ± 1.05 s). Physical stability studies at 40 °C/75% RH for 6 months, showed that the formulation was stable. |
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Formulation Design and in vitro Evaluation of Orodispersible Tablets of Orlistat by Direct Compression Method |
PEARLITOL® Flash Co-processed Mannitol-Starch |
Formulation containing 6% of PEARLITOL® Flash and 6% of Croscarmellose Sodium was found with very short in vitro disintegration time of 18s together with a fast dissolution of the API. |
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Stability of Benzocaine Formulated in Commercial Oral Disintegrating Tablet Platforms |
PEARLITOL® Flash Co-processed Mannitol-Starch |
The stability of benzocaine Orally Disintegrating Tablets formulated with PEARLITOL® Flash was very high in drastic storage conditions (6 months at 40°C/77% RH): chemical inertness and no change of the physical appearance). |
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Bioenhanced sublingual tablet of drug with limited permeability using novel surfactant binder and microencapsulated polysorbate: in vitro/in vivo evaluation |
PEARLITOL® Flash Co-processed Mannitol-Starch |
Bioenhanced sublingual tablets of zolmitriptan containing 33% of PEARLITOL® Flash showed the shortest in vitro/in vivo disintegration times (<30 s), the highest dissolution at early time dissolution points and the highest enhancement of drug transport through mucosal membrane. |
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Orally disintegrating mini-tablets (ODMTs) – A novel solid oral dosage form for paediatric use |
PEARLITOL® Flash Co-processed Mannitol-Starch |
Powder mixtures for direct compression containing PEARLITOL® Flash present the best flow properties. In addition, ODMTs using PEARLITOL® Flash show high performance in term of simulated wetting time (between 4s and 6s). |
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Micronized Zaleplon Delivery via Orodispersible Film and Orodispersible Tablets |
PEARLITOL® Flash Co-processed Mannitol-Starch |
The use of PEARLITOL® Flash in the ODT formulation enabled to reach adequate harness together with smooth texture and short disintegration time of 30+/-5 seconds. |
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