Formulation containing 50% of StarLac® was found with shortest in vitro, in vitro in artificial saliva and in vivo disintegration times, respectively (21.7 ± 1.67 s), (22.5 ± 1.67 s) and (24.0 ± 1.05 s). Physical stability studies at 40 °C/75% RH for 6 months, showed that the formulation was stable.
Formulation Design and in vitro Evaluation of Orodispersible Tablets of Orlistat by Direct Compression Method
The stability of benzocaine Orally Disintegrating Tablets formulated with PEARLITOL® Flash was very high in drastic storage conditions (6 months at 40°C/77% RH): chemical inertness and no change of the physical appearance).
Bioenhanced sublingual tablet of drug with limited permeability using novel surfactant binder and microencapsulated polysorbate: in vitro/in vivo evaluation
Bioenhanced sublingual tablets of zolmitriptan containing 33% of PEARLITOL® Flash showed the shortest in vitro/in vivo disintegration times (<30 s), the highest dissolution at early time dissolution points and the highest enhancement of drug transport through mucosal membrane.
Orally disintegrating mini-tablets (ODMTs) – A novel solid oral dosage form for paediatric use
Powder mixtures for direct compression containing PEARLITOL® Flash present the best flow properties. In addition, ODMTs using PEARLITOL® Flash show high performance in term of simulated wetting time (between 4s and 6s).
Micronized Zaleplon Delivery via Orodispersible Film and Orodispersible Tablets