hydroxypropyl-betacyclodextrin HPB and HP-Parenteral grade
KLEPTOSE® HPB & HP hydroxypropyl-betacyclodextrin parenteral grade materials that are used as encapsulating agents for Rx injectables. These are modified betacyclodextrins for parenteral use. Modified betacyclodextrins used in parenteral preparations provide active substance stabilization improvement against light and oxidation as well as enhancement of solubilization of active pharmaceutical ingredients.
Molecular encapsulation with modified beta-cyclodextrins has become an accepted and useful tool for pharmaceutical developers. There are currently several pharmaceutical products containing modified cyclodextrin complexes on the market. Roquette has pioneered the industrial development of cyclodextrins with its KLEPTOSE® range of betacyclodextrins.
hydroxypropyl-betacyclodextrin (HPBCD) is a white, amorphous powder. The HPBCD molecule is a torus shaped ring with a polar hydrophilic outside and an apolar hydrophobic cavity.