NEOSORB® P 650 DC
Sorbitol
| Product Name | NEOSORB® P 650 DC |
| Generic Name | Sorbitol Pharma |
| Physico-chemical properties | |
| Compliance | EP/USP-NF |
| Replacement for | NEOSORB® XTAB 650 |
| Synonyms | D-Glucitol |
| CAS Number | 50-70-4 |
| Chemical Structure |
|
| Average Molecular Weight | 182.2 g/mol |
| Physical Form or Appearence | White or almost white crystalline powder |
| Application | NEOSORB® P 650 DC sorbitol is a direct compression excipient. It is a non-cariogenic and non-acidogenic sugar-free sweetener that is suitable for chewable, suckable or effervescent tablets. |
| Water content (LOD) |
Nominal water content: 0.3 % Water Content (LOD) Maximum: 1.5 % |
| Morphology |
|
| Average mean particle diameter | 650 µm |
| Particle Size Distribution by Laser Diffraction |
dv10: 490 µm dv50: 770 µm dv90: 1100 µm |
| Solubility | Very soluble in water (235 g/100 ml of water at 25°C), practically insoluble in ethanol (96%) |
| Melting temperature |
Minimum melting temperature : 95 °C Maximum melting temperature: 98 °C |
| Water sorption isotherm at 20°C |
|
| Taste/Odor | Slightly sweet (sweetening power about 50-60% that of sucrose) with cooling effect due to high dissolution enthalpy in water (111 J/g) |
| Tablet hardness |
|
| Experimental Conditions for Compression Behavior |
Tablet Press: STYLCAM 200R Production Speed: 10, 25 and 40 tablets/min (respective linear punch velocity: 38, 96 and 152 mm/s ; respective simulated rotary press speed: 60000, 150000 and 250000 tablets/hour) Tooling: Diameter 10 mm R9 concave Formula: 99.3% NEOSORB® P 650 DC / 0.7% magnesium stearate Tablet Mass: 400 mg |
| Powder Characteristics |
Powder Flowability (according to Ph.Eur. 2.9.16, 10mm outflow opening): 11 s Bulk Density: 0.59 g/cm3 Tapped Density: 0.7 g/cm3 True Density: 1.507 g/cm3 Specific surface area: 1.55 m2/g Angle of Repose: 32 ° |
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