NEOSORB® P 650 DC
Sorbitol
Product Profile

NEOSORB® P 650 DC
Sorbitol

Product Name NEOSORB® P 650 DC
Generic Name Sorbitol Pharma
Physico-chemical properties
Compliance EP/USP-NF
Replacement for NEOSORB® XTAB 650
Synonyms D-Glucitol
CAS Number 50-70-4
Chemical Structure
Average Molecular Weight 182.2 g/mol
Physical Form or Appearence White or almost white crystalline powder
Application NEOSORB® P 650 DC sorbitol is a direct compression excipient. It is a non-cariogenic and non-acidogenic sugar-free sweetener that is suitable for chewable, suckable or effervescent tablets.
Water content (LOD)

Nominal water content: 0.3 %

Water Content (LOD) Maximum: 1.5 %

Morphology
Average mean particle diameter 650 µm
Particle Size Distribution by Laser Diffraction

dv10: 490 µm

dv50: 770 µm

dv90: 1100 µm

Solubility Very soluble in water (235 g/100 ml of water at 25°C), practically insoluble in ethanol (96%)
Melting temperature

Minimum melting temperature : 95 °C

Maximum melting temperature: 98 °C

Water sorption isotherm at 20°C
Taste/Odor Slightly sweet (sweetening power about 50-60% that of sucrose) with cooling effect due to high dissolution enthalpy in water (111 J/g)
Tablet hardness
Experimental Conditions for Compression Behavior

Tablet Press: STYLCAM 200R

Production Speed: 10, 25 and 40 tablets/min (respective linear punch velocity: 38, 96 and 152 mm/s ; respective simulated rotary press speed: 60000, 150000 and 250000 tablets/hour)

Tooling: Diameter 10 mm R9 concave

Formula: 99.3% NEOSORB® P 650 DC / 0.7% magnesium stearate

Tablet Mass: 400 mg

Powder Characteristics

Powder Flowability (according to Ph.Eur. 2.9.16, 10mm outflow opening): 11 s

Bulk Density: 0.59 g/cm3

Tapped Density: 0.7 g/cm3

True Density: 1.507 g/cm3

Specific surface area: 1.55 m2/g

Angle of Repose: 32 °

 

Disclaimer

These typical values are provided for information only and we believe them to be reliable. Methods available upon request.

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