MICROCEL® 112 SD Microcrystalline Cellulose
Product Profile

MICROCEL® 112 SD Microcrystalline Cellulose

 
Product Name MICROCEL® 112 SD
Generic Name Microcrystalline Cellulose
Physico-chemical properties
Compliance

EP/USP-NF/JP/CHP

Synonyms

Cellulose, Microcrystalline

CAS Number

9004-34-6

Chemical Structure
Physical Form or Appearence

White, non-fibrous powder

Application

MICROCEL® 112 SD microcrystalline cellulose is a low moisture content direct compression excipient and fiber source for pharmaceutical oral dosage and nutraceutical forms. It has a high compactibility and is also suitable for dry granulation. MICROCEL® 112 SD is a spray-dried product from EXCiPACT™ (International Pharmaceutical Excipients Certification) certified plant. 

Water content (LOD)

Water Content (LOD) Maximum: 1.5 %

Morphology
Average mean particle diameter 100 µm
Particle Size Distribution by Laser Diffraction

dv10: 49 µm

dv50: 130 µm

dv90: 256 µm

Solubility

Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents

Water sorption isotherm at 20°C
Taste/Odor

Odorless and tasteless

Tablet hardness
Experimental Conditions for Compression Behavior

Tablet Press: STYL'ONE EVO

Production Speed: 10, 20 and 40 RPM (linear punch velocity: 14, 28 and 56 mm/s; simulated KORSCH XL-400 rotary press speed: 21,000, 42,000 and 84,000 tablets/hour)

Tooling: Diameter 10 mm flat

Formula: MICROCEL® 112 SD, microcrystalline cellulose

Tablet Mass: 400 mg

Powder Characteristics

Powder Flowability (according to Ph.Eur. 2.9.16, 10mm outflow opening): 7 s

Bulk Density: 0.31 g/cm3

Tapped Density: 0.46 g/cm3

True Density: 1.54 g/cm3

Specific surface area: 1.3 m2/g

Angle of Repose: 35 °

Water activity: 0.16

The information contained in this document is to the best of our knowledge true and accurate, but all instructions, recommendations or suggestions are made without guarantee. Since the conditions of use are beyond our control, we disclaim any liability for loss and/or damage suffered from use of these data or suggestions. Furthermore, no liability is accepted if use of any product in accordance with these data or suggestions infringes any patent. No part of this document may be reproduced by any process without our prior written permission.

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