MICROCEL® 112 SD Microcrystalline Cellulose
| Product Name | MICROCEL® 112 SD |
| Generic Name | Microcrystalline Cellulose |
| Physico-chemical properties | |
| Compliance | EP/USP-NF/JP/CHP |
| Synonyms | Cellulose, Microcrystalline |
| CAS Number | 9004-34-6 |
| Chemical Structure |
|
| Physical Form or Appearence | White, non-fibrous powder |
| Application | MICROCEL® 112 SD microcrystalline cellulose is a low moisture content direct compression excipient and fiber source for pharmaceutical oral dosage and nutraceutical forms. It has a high compactibility and is also suitable for dry granulation. MICROCEL® 112 SD is a spray-dried product from EXCiPACT™ (International Pharmaceutical Excipients Certification) certified plant. |
| Water content (LOD) |
Water Content (LOD) Maximum: 1.5 % |
| Morphology |
|
| Average mean particle diameter | 100 µm |
| Particle Size Distribution by Laser Diffraction |
dv10: 49 µm dv50: 130 µm dv90: 256 µm |
| Solubility | Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents |
| Water sorption isotherm at 20°C |
|
| Taste/Odor | Odorless and tasteless |
| Tablet hardness |
|
| Experimental Conditions for Compression Behavior |
Tablet Press: STYL'ONE EVO Production Speed: 10, 20 and 40 RPM (linear punch velocity: 14, 28 and 56 mm/s; simulated KORSCH XL-400 rotary press speed: 21,000, 42,000 and 84,000 tablets/hour) Tooling: Diameter 10 mm flat Formula: MICROCEL® 112 SD, microcrystalline cellulose Tablet Mass: 400 mg |
| Powder Characteristics |
Powder Flowability (according to Ph.Eur. 2.9.16, 10mm outflow opening): 7 s Bulk Density: 0.31 g/cm3 Tapped Density: 0.46 g/cm3 True Density: 1.54 g/cm3 Specific surface area: 1.3 m2/g Angle of Repose: 35 ° Water activity: 0.16 |
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