Vitamin E Chewable Tablets Using PEARLITOL® 200 SD Mannitol and XYLISORB® 300 Xylitol
Directly compressible formulation for vitamin E chewable tablets
Formula
|
|
% (by weight)
|
mg / tablet
|
|---|---|---|
|
PEARLITOL® 200 SD mannitol
|
43.93
|
659.0
|
|
XYLISORB® 300 xylitol
|
43.93
|
659.0
|
|
KLEPTOSE® βCD beta-cyclodextrin
|
7.67
|
115.0
|
|
DLα tocopherol acetate
|
1.67
|
25.0
|
|
Magnesium stearate
|
1.50
|
22.5
|
|
Mint flavor (Firmenich)
|
0.60
|
9.0
|
|
Citric acid
|
0.40
|
6.0
|
|
Lemon flavor (Firmenich)
|
0.30
|
4.5
|
Method
- Mix KLEPTOSE® βCD and water into a double jacket mixer heated to 50°C.
- Introduce tocopherol acetate and mix for 2 hours.
- Dry the mix in a drying oven at 45°C.
- Grind the dry complex KLEPTOSE® βCD / tocopherol acetate.
- Mix PEARLITOL® 200 SD, XYLISORB® 300, dry complex, citric acid and flavors for 5 minutes.
- Add magnesium stearate and mix for 5 minutes.
- Compress the powder with 18 mm flat face punches.
Additional comments
- Tablet weight: 1500 mg
- Tablet thickness: 4.70 mm
- Tablet density: 1.25 g/cm3
- Tablet hardness: 80 N
- Dosage: 25 mg vitamin E / 1500 mg tablet
Disclaimer
This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s).
These details are for information only and we believe them to be reliable.